2017 Outbreak of Ebola Virus Disease in Northern Democratic Republic of Congo

被引：16

作者：

Nsio, Justus ^{[1
]}

Kapetshi, Jimmy ^{[2
]}

Makiala, Sheila ^{[2
]}

Raymond, Frederic ^{[4
]}

Tshapenda, Gaston ^{[1
]}

Boucher, Nancy ^{[4
]}

Corbeil, Jacques ^{[4
]}

Okitandjate, Antoine ^{[1
]}

Mbuyi, Gisele ^{[1
]}

Kiyele, Musa ^{[1
]}

Mondonge, Vital ^{[3
]}

Kikoo, Marie Jose ^{[3
]}

Van Herp, Michel ^{[6
]}

Barboza, Philippe ^{[5
]}

Petrucci, Roberta ^{[6
]}

Benedetti, Guido ^{[7
]}

Formenty, Pierre ^{[5
]}

Muzinga, Baby Muyembe ^{[2
]}

Kalenga, Oly Ilunga ^{[1
]}

Ahuka, Steve ^{[2
]}

Fausther-Bovendo, Hugues ^{[4
]}

Ilunga, Benoit Kebela ^{[1
]}

Kobinger, Gary P. ^{[4
]}

Muyembe, Jean-Jacques T. ^{[2
]}

机构：

[1] Minist Hlth, Kinshasa, DEM REP CONGO

[2] Inst Natl Rech Biomed, Kinshasa, DEM REP CONGO

[3] WHO, Kinshasa, DEM REP CONGO

[4] Univ Laval, Quebec City, PQ, Canada

[5] WHO, Geneva, Switzerland

[6] MSF, Geneva, Switzerland

[7] MSF, Operat Ctr Brussels, Med Dept, Luxembourg, Luxembourg

来源：

JOURNAL OF INFECTIOUS DISEASES | 2020年 / 221卷 / 05期

关键词：

Ebola virus; outbreak; virus sequence; DIAGNOSIS;

D O I：

10.1093/infdis/jiz107

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. In 2017, the Democratic Republic of the Congo (DRC) recorded its eighth Ebola virus disease (EVD) outbreak, approximately 3 years after the previous outbreak. Methods. Suspect cases of EVD were identified on the basis of clinical and epidemiological information. Reverse transcription-polymerase chain reaction (RT-PCR) analysis or serological testing was used to confirm Ebola virus infection in suspected cases. The causative virus was later sequenced from a RT-PCR-positive individual and assessed using phylogenetic analysis. Results. Three probable and 5 laboratory-confirmed cases of EVD were recorded between 27 March and 1 July 2017 in the DRC. Fifty percent of cases died from the infection. EVD cases were detected in 4 separate areas, resulting in > 270 contacts monitored. The complete genome of the causative agent, a variant from the Zaireebolavirus species, denoted Ebola virus Muyembe, was obtained using next-generation sequencing. This variant is genetically closest, with 98.73% homology, to the Ebola virus Mayinga variant isolated from the first DRC outbreaks in 1976-1977. Conclusion. A single spillover event into the human population is responsible for this DRC outbreak. Human-to-human transmission resulted in limited dissemination of the causative agent, a novel Ebola virus variant closely related to the initial Mayinga variant isolated in 1976-1977 in the DRC.

引用

页码：701 / 706

页数：6