The Intricate Metabolism of Pancreatic Cancers

被引：12

作者：

Camelo, Felipe ^{[1
]}

Le, Anne ^{[2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Pathol & Oncol, Baltimore, MD 21205 USA

来源：

HETEROGENEITY OF CANCER METABOLISM | 2018年 / 1063卷

关键词：

Pancreatic ductal adenocarcinoma; KRAS mutation; Glucose metabolism; Glutamine metabolism; Combined therapy; METFORMIN; KRAS; COMBINATION; PATHWAY; CPI-613; AGENT;

D O I：

10.1007/978-3-319-77736-8_5

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：73 / 81

页数：9

共 29 条

[1] Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: a single-centre, open-label, dose-escalation, phase 1 trial [J].

Alistar, Angela ;

Morris, Bonny B. ;

Desnoyer, Rodwige ;

Klepin, Heidi D. ;

Hosseinzadeh, Keyanoosh ;

Clark, Clancy ;

Cameron, Amy ;

Leyendecker, John ;

D'Agostino, Ralph, Jr. ;

Topaloglu, Umit ;

Boteju, Lakmal W. ;

Boteju, Asela R. ;

Shorr, Rob ;

Zachar, Zuzana ;

Bingham, Paul M. ;

Ahmed, Tamjeed ;

Crane, Sandrine ;

Shah, Riddhishkumar ;

Migliano, John J. ;

Pardee, Timothy S. ;

Miller, Lance ;

Hawkins, Gregory ;

Jin, Guangxu ;

Zhang, Wei ;

Pasche, Boris .

LANCET ONCOLOGY, 2017, 18 (06) :770-778

[2]

[Anonymous], CELL

[3] TIGAR, a p53-inducible regulator of glycolysis and apoptosis [J].

Bensaad, Karim ;

Tsuruta, Atsushi ;

Selak, Mary A. ;

Calvo Vidal, M. Nieves ;

Nakano, Katsunori ;

Bartrons, Ramon ;

Gottlieb, Eyal ;

Vousden, Karen H. .

CELL, 2006, 126 (01) :107-120

[4] Genome Profiling of Pancreatic Adenocarcinoma [J].

Birnbaum, David J. ;

Adelaide, Jose ;

Mamessier, Emilie ;

Finetti, Pascal ;

Lagarde, Arnaud ;

Monges, Genevieve ;

Viret, Frederic ;

Goncalves, Anthony ;

Turrini, Olivier ;

Delpero, Jean-Robert ;

Iovanna, Juan ;

Giovannini, Marc ;

Birnbaum, Daniel ;

Chaffanet, Max .

GENES CHROMOSOMES & CANCER, 2011, 50 (06) :456-465

[5] MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer [J].

Chaika, Nina V. ;

Gebregiworgis, Teklab ;

Lewallen, Michelle E. ;

Purohit, Vinee ;

Radhakrishnan, Prakash ;

Liu, Xiang ;

Zhang, Bo ;

Mehla, Kamiya ;

Brown, Roger B. ;

Caffrey, Thomas ;

Yu, Fang ;

Johnson, Keith R. ;

Powers, Robert ;

Hollingsworth, Michael A. ;

Singh, Pankaj K. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (34) :13787-13792

[6] Differential Expression of Metabolic Genes in Tumor and Stromal Components of Primary and Metastatic Loci in Pancreatic Adenocarcinoma [J].

Chaika, Nina V. ;

Yu, Fang ;

Purohit, Vinee ;

Mehla, Kamiya ;

Lazenby, Audrey J. ;

DiMaio, Dominick ;

Anderson, Judy M. ;

Yeh, Jen Jen ;

Johnson, Keith R. ;

Hollingsworth, Michael A. ;

Singh, Pankaj K. .

PLOS ONE, 2012, 7 (03)

[7] Roles for KRAS in Pancreatic Tumor Development and Progression [J].

di Magliano, Marina Pasca ;

Logsdon, Craig D. .

GASTROENTEROLOGY, 2013, 144 (06) :1220-1229

[8] Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer [J].

Elgogary, Amira ;

Xu, Qingguo ;

Poore, Brad ;

Alt, Jesse ;

Zimmermann, Sarah C. ;

Zhao, Liang ;

Fu, Jie ;

Chen, Baiwei ;

Xia, Shiyu ;

Liu, Yanfei ;

Neisser, Marc ;

Nguyen, Christopher ;

Lee, Ramon ;

Park, Joshua K. ;

Reyes, Juvenal ;

Hartung, Thomas ;

Rojas, Camilo ;

Rais, Rana ;

Tsukamoto, Takashi ;

Semenza, Gregg L. ;

Hanes, Justin ;

Slusher, Barbara S. ;

Le, Anne .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (36) :E5328-E5336

[9] Metformin and reduced risk of cancer in diabetic patients [J].

Evans, JMM ;

Donnelly, LA ;

Emslie-Smith, AM ;

Alessi, DR ;

Morris, AD .

BMJ-BRITISH MEDICAL JOURNAL, 2005, 330 (7503) :1304-1305

[10] Analysis of mortality rates for pancreatic cancer across the world [J].

Hariharan, D. ;

Saied, A. ;

Kocher, H. M. .

HPB, 2008, 10 (01) :58-62

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