A practical enantioselective synthesis of Epibatidine

被引：39
作者：
Szantay, C
KardosBalogh, Z
Moldvai, I
Szantay, C
TemesvariMajor, E
Blasko, G
机构：
[1] GEDEON RICHTER CHEM WORKS LTD,CHEM WORKS,SPECTROSCOP RES DIV,H-1475 BUDAPEST,HUNGARY
[2] EGIS PHARMACEUT,H-1475 BUDAPEST,HUNGARY
来源：
TETRAHEDRON | 1996年 / 52卷 / 33期
关键词：
D O I：
10.1016/0040-4020(96)00623-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two different syntheses of Epibatidine (1) were designed and carried out using easily accessible reagents and convenient reaction conditions. The ring closure of the prochiral precursor 4 catalyzed by optically active alpha-phenyl-ethyl-amine gave the key intermediate 5 in over 80% ee from which the natural product (-)-1 has been prepared. Copyright (C) 1996 Elsevier Science Ltd
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收藏
页码：11053 / 11062
页数：10
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