Are Low Serum Vitamin D Levels a Risk Factor for Advent of COVID-19 Associated Rhinocerebral Mucormycosis: A Preliminary Case Control Study

被引：5

作者：

Popli, Harsha ^{[1
]}

Gupta, Ambika ^{[1
]}

Singh, Virendra ^{[2
]}

Agarwal, Varsha ^{[1
]}

Akilan, R. ^{[2
]}

Kumar, Adarsh ^{[3
]}

机构：

[1] Post Grad Inst Dent Sci, Dept Oral Med & Radiol, Rohtak, Haryana, India

[2] Post Grad Inst Dent Sci, Dept Oral & Maxillofacial Surg, Rohtak, Haryana, India

[3] Post Grad Inst Dent Sci, Dept Publ Hlth Dent, Rohtak, Haryana, India

来源：

INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY | 2022年 / 74卷 / SUPPL 2期

关键词：

Coronavirus disease (COVID-19); Mucormycosis; Rhinocerebral Mucormycosis; Vitamin D(25-hydroxycholecalciferol); 25-HYDROXYVITAMIN D; RESISTANCE;

D O I：

10.1007/s12070-022-03080-7

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

To determine whether low serum vitamin D level is a risk factor for development of Rhinocerebral mucormycosis in COVID-19 afflicted patients. A case control study was conducted in a tertiary care hospital utilizing the archived records of COVID-19 afflicted Rhinocerebral mucormycosis cases and age and gender matched controls. The mean value (+/- standard deviation) of vitamin D level in patients with Mucormycosis was 19.65 +/- 13.07 ng/ml and in control subjects it was 27.88 +/- 18.04 ng/ml.There was a significant difference between groups (p = 0.02). Thus, low Vitamin D level may be implicated as a risk factor for the advent of mucormycosis in a COVID-19 afflicted patient and therefore Vitamin D supplements may be provided to such patients to achieve normal serum levels.

引用

页码：3529 / 3533

页数：5

共 30 条

[1] The association between the level of serum 25(OH) vitamin D, obesity, and underlying diseases with the risk of developing COVID-19 infection: A case-control study of hospitalized patients in Tehran, Iran [J].

Abdollahi, Alireza ;

Sarvestani, Hasti Kamali ;

Rafat, Zahra ;

Ghaderkhani, Sara ;

Mahmoudi-Aliabadi, Maedeh ;

Jafarzadeh, Bita ;

Mehrtash, Vahid .

JOURNAL OF MEDICAL VIROLOGY, 2021, 93 (04) :2359-2364

[2]

Agarwal V, 2022, J MAXILLOFAC ORAL SU, V21, P990, DOI [10.1007/s12663-021-01665-3, 10.1080/15378020.2021.1951074]

[3]

Amer Diabet Assoc, 2013, DIABETES CARE, V36, pS67, DOI [10.2337/dc12-s064, 10.2337/dc10-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc12-s011, 10.2337/dc11-S062, 10.2337/dc14-S081, 10.2337/dc10-S062, 10.2337/dc13-S011]

[4]

[Anonymous], 2015, Asthma Res Pract, DOI DOI 10.1186/S40733-015-0003-5

[5] Vitamin D3 a new drug against Candida albicans [J].

Bouzid, D. ;

Merzouki, S. ;

Bachiri, M. ;

Ailane, S. E. ;

Zerroug, M. M. .

JOURNAL DE MYCOLOGIE MEDICALE, 2017, 27 (01) :79-82

[6]

Dai JJ, 2018, AM J TRANSL RES, V10, P381

[7] Coronavirus Disease (Covid-19) Associated Mucormycosis (CAM): Case Report and Systematic Review of Literature [J].

Garg, Deepak ;

Muthu, Valliappan ;

Sehgal, Inderpaul Singh ;

Ramachandran, Raja ;

Kaur, Harsimran ;

Bhalla, Ashish ;

Puri, Goverdhan D. ;

Chakrabarti, Arunaloke ;

Agarwal, Ritesh .

MYCOPATHOLOGIA, 2021, 186 (02) :289-298

[8] The vitamin D-antimicrobial peptide pathway and its role in protection against infection [J].

Gombart, Adrian F. .

FUTURE MICROBIOLOGY, 2009, 4 (09) :1151-1165

[9]

Holick MF, 2008, AM J CLIN NUTR, V87, p1080S

[10] Rhizopus oryzae adheres to, is phagocytosed by, and damages endothelial cells in vitro [J].

Ibrahim, AS ;

Spellberg, B ;

Avanessian, V ;

Fu, Y ;

Edwards, JE .

INFECTION AND IMMUNITY, 2005, 73 (02) :778-783

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