A golden bullet?: Selective targeting of toxoplasma gondii tachyzoites using anti body-functionalized gold nanorods

被引：127

作者：

Pissuwan, Dakrong ^{[1
]}

Valenzuela, Stella M. ^{[2
]}

Miller, Catherine M. ^{[3
]}

Cortie, Michael B. ^{[1
]}

机构：

[1] Univ Technol Sydney, Inst Nanoscale Technol, Sydney, NSW 2006, Australia

[2] Univ Technol Sydney, Dept Med & Mol Biosci, Sydney, NSW 2006, Australia

[3] Univ Technol Sydney, Inst Biotechnol & Infect Dis, Sydney, NSW 2006, Australia

来源：

NANO LETTERS | 2007年 / 7卷 / 12期

关键词：

D O I：

10.1021/nl072377+

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Conjugates of gold nanoparticles and antibodies have useful functionalities. Here, we show how they can be used to selectively target and destroy parasitic protozoans. Gold nanorods were conjugated with an anti-Toxoplasma gondii antibody and used to target the extracellular tachyzoite which is an infectious form of an obligate parasite Toxoplasma gondii. Subsequent laser irradiation was used to kill the targeted protozoans. This concept provides a new paradigm for the treatment of parasitic protozoans.

引用

页码：3808 / 3812

页数：5

共 35 条

[1] Host persistence:: Exploitation of anti-inflammatory pathways by Toxoplasma gondii [J].

Aliberti, J .

NATURE REVIEWS IMMUNOLOGY, 2005, 5 (02) :162-170

[2]

[Anonymous], 2000, Congenital toxoplasmosis : scientific background, clinical management, and control

[3] Lytic cycle of Toxoplasma gondii [J].

Black, MW ;

Boothroyd, JC .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2000, 64 (03) :607-+

[4] Safety assessment of near infrared light emitting diodes for diffuse optical measurements [J].

Bozkurt, Alper ;

Onaral, Banu .

BIOMEDICAL ENGINEERING ONLINE, 2004, 3 (1)

[5] Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells [J].

Chithrani, BD ;

Ghazani, AA ;

Chan, WCW .

NANO LETTERS, 2006, 6 (04) :662-668

[6] Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity [J].

Connor, EE ;

Mwamuka, J ;

Gole, A ;

Murphy, CJ ;

Wyatt, MD .

SMALL, 2005, 1 (03) :325-327

[7] Selective laser photo-thermal therapy of epithelial carcinoma using anti-EGFR antibody conjugated gold nanoparticles [J].

El-Sayed, Ivan H. ;

Huang, Xiaohua ;

El-Sayed, Mostafa A. .

CANCER LETTERS, 2006, 239 (01) :129-135

[8] Cell-culture system for continuous production of Toxoplasma gondii tachyzoites [J].

Evans, R ;

Chatterton, JMW ;

Ashburn, D ;

Joss, AWL ;

Ho-Yen, DO .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1999, 18 (12) :879-884

[9] A whole blood immunoassay using gold nanoshells [J].

Hirsch, LR ;

Jackson, JB ;

Lee, A ;

Halas, NJ ;

West, J .

ANALYTICAL CHEMISTRY, 2003, 75 (10) :2377-2381

[10] Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance [J].

Hirsch, LR ;

Stafford, RJ ;

Bankson, JA ;

Sershen, SR ;

Rivera, B ;

Price, RE ;

Hazle, JD ;

Halas, NJ ;

West, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (23) :13549-13554

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