Ultrasonographic features of medullary thyroid carcinoma and their diagnostic values

被引:14
作者
Cai Sheng [1 ,2 ]
Liu He [1 ,2 ]
Li Wen-bo [1 ,2 ]
Ouyang Yun-shu [1 ,2 ]
Zhang Bo [1 ,2 ]
Li Peng [1 ,2 ]
Wang Xue-lian [3 ]
Zhang Xiao-yan [1 ,2 ]
Li Jian-chu [1 ,2 ]
Jiang Yu-xin [1 ,2 ]
机构
[1] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Ultrasound, Beijing 100730, Peoples R China
[2] Peking Union Med Coll, Beijing 100730, Peoples R China
[3] Beijing 6th Hosp, Dept Ultrasound, Beijing 100007, Peoples R China
关键词
colour Doppler ultrasonography; medullary thyroid carcinoma; thyroid nodule; COLOR DOPPLER SONOGRAPHY; NODULES; ULTRASOUND; MALIGNANCY; CANCER; US; MANAGEMENT; CRITERIA; BENIGN; BIOPSY;
D O I
10.3760/cma.j.issn.0366-6999.2010.21.022
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Medullary thyroid carcinoma (MTC) is a rare malignant tumour and usually difficult to diagnose with ultrasound. The aim of the study is to summarize the sonographic features of MTC and evaluate their diagnostic values. Methods We analyzed the sonographic features of 35 MTCs and 50 benign nodules with respect to nodular size, echogenecity, internal content, shape, height/width, border, peripheral halo, calcifications and colour flow pattern. The ratio of long to short axis, echogenecity, internal content and calcifications were also assessed in cervical lymph nodes. The differences in sonographic features between MTCs and benign nodules were analyzed with Chi square test. The diagnostic efficiency of each sonographic feature was determined. Results The main sonographic features of MTC were hypoechogenicity (including marked hypoechogenicity) (n=34, 97%), internal solid content (n=29, 83%), taller than wide (n=34, 97%), well defined border (n=24, 69%), microcalcifications or macrocalcifications (n=23, 66%). The echogenicity, internal content, shape, peripheral halo and calcifications were significantly different between these two groups, while the tall/wide, border, and perinodular and intranodular vascularisation were not significantly different. Among all the individual sonographic features, irregular shape had the highest diagnostic efficiency with a sensitivity of 51% and specificity of 92%. The combination of marked hypoechogenicity, microcalcifications, and irregular shape yielded a sensitivity of 77% and specificity of 86%. Conclusions The typical sonographic features of MTC are hypoechogenicity, predominantly solid, irregularly shaped with intranodular micro- or macro-calcifications. The combination of multiple sonographic features is helpful, but not definitive, for the diagnosis of MTC. Chin Med J 2010;123(21):3074-3078
引用
收藏
页码:3074 / 3078
页数:5
相关论文
共 50 条
[41]   Papillary thyroid carcinoma on sonography [J].
Li, Quan-shui ;
Chen, Sheng-hua ;
Xiong, Hua-hua ;
Xu, Xiao-hua ;
Li, Zhen-zhou ;
Guo, Guo-qiang .
CLINICAL IMAGING, 2010, 34 (02) :121-126
[42]   The Prognostic Relevance of Psammoma Bodies and Ultrasonographic Intratumoral Calcifications in Papillary Thyroid Carcinoma [J].
Pyo, Jung-Soo ;
Kang, Guhyun ;
Kim, Dong-Hoon ;
Park, Chanheun ;
Kim, Joo Heon ;
Sohn, Jin Hee .
WORLD JOURNAL OF SURGERY, 2013, 37 (10) :2330-2335
[43]   Sonographic Features of Thyroid Follicular Carcinoma in Comparison With Thyroid Follicular Adenoma [J].
Zhang, Ji-Zhen ;
Hu, Bing .
JOURNAL OF ULTRASOUND IN MEDICINE, 2014, 33 (02) :221-227
[44]   The diagnostic challenges of medullary thyroid carcinoma: A practical guide for cytopathologists [J].
Pusztaszeri, Marc P. ;
Maleki, Zahra .
CANCER CYTOPATHOLOGY, 2025, 133 (06)
[45]   Positive predictive values of sonographic features of solid thyroid nodule [J].
Hong, Yoo Jin ;
Son, Eun Ju ;
Kim, Eun-Kyung ;
Kwak, Jin Young ;
Hong, Soon Won ;
Chang, Hang-Seok .
CLINICAL IMAGING, 2010, 34 (02) :127-133
[46]   Comparison of the diagnostic performance and clinical role of different ultrasound-based thyroid malignancy risk stratification systems for medullary thyroid carcinoma [J].
Jiang, Liu ;
Zhu, Hai-Bin ;
Liang, Zhen-Wei ;
Chen, Lei ;
Sun, Xiu-Ming ;
Shao, Yu-Hong ;
Chen, Lu-Zeng .
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY, 2023, 13 (06) :3776-3788
[47]   Predictive Factors for Occult Contralateral Carcinoma in Patients with Unilateral Papillary Thyroid Microcarcinoma by Preoperative Ultrasonographic and Pathological Features [J].
Lee, Young Chan ;
Eun, Young Gyu ;
Sohn, Yu-Mee ;
Rhee, Sang Youl ;
Hong, Il Ki ;
Chon, Suk ;
Oh, Seung Joon ;
Kim, Deog Yoon .
WORLD JOURNAL OF SURGERY, 2015, 39 (07) :1736-1741
[48]   Ultrasound features value in the diagnosis and prognosis of medullary thyroid carcinoma [J].
Zhao, Jing ;
Yang, Fan ;
Wei, Xi ;
Mao, Yiran ;
Mu, Jie ;
Zhao, Lihui ;
Wu, Jianghua ;
Xin, Xiaojie ;
Zhang, Sheng ;
Tan, Jian .
ENDOCRINE, 2021, 72 (03) :727-734
[49]   New Opportunities for Preoperative Diagnosis of Medullary Thyroid Carcinoma [J].
Lukyanov, Sergei A. A. ;
Sergiyko, Sergei V. V. ;
Titov, Sergei E. E. ;
Beltsevich, Dmitry G. G. ;
Veryaskina, Yulia A. A. ;
Vanushko, Vladimir E. E. ;
Urusova, Liliya S. S. ;
Mikheenkov, Alexander A. A. ;
Kozorezova, Evgeniya S. S. ;
Vorobyov, Sergey L. L. ;
Sleptsov, Ilya V. V. .
BIOMEDICINES, 2023, 11 (05)
[50]   Follicular Variant of Papillary Thyroid Carcinoma: Distinct Biologic Behavior Based on Ultrasonographic Features [J].
Rhee, Sun Jung ;
Hahn, Soo Yeon ;
Ko, Eun Sook ;
Ryu, Jae Wook ;
Ko, Eun Young ;
Shin, Jung Hee .
THYROID, 2014, 24 (04) :683-688