Randomized study of chemotherapy and surgery versus radiotherapy for stage IIIA non-small-cell lung cancer: a National Cancer Institute of Canada Clinical Trials Group Study

被引：55
|
作者：
Shepherd, FA
Johnston, MR
Payne, D
Burkes, R
Deslauriers, J
Cormier, Y
de Bedoya, LD
Ottaway, J
James, K
Zee, B
机构：
[1] Univ Toronto, Interdept Div Oncol, Toronto, ON, Canada
[2] Hop Laval, St Foy, PQ, Canada
[3] Univ Laval, St Foy, PQ G1K 7P4, Canada
[4] Natl Canc Inst, Canada Clin Trials Grp, Kingston, ON, Canada
[5] Queens Univ, Kingston, ON, Canada
来源：
BRITISH JOURNAL OF CANCER | 1998年 / 78卷 / 05期
关键词：
induction chemotherapy; combined-modality therapy; non-small-cell lung cancer;
D O I：
10.1038/bjc.1998.560
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Thirty-one patients with stage IIIA (N2) non-small-cell lung cancer were randomized to receive radiotherapy alone or chemotherapy with cisplatin and vinblastine followed by surgery. Response rates to induction chemotherapy and radiotherapy were 50% and 53.3% respectively. Complete surgical resection was possible for 62.5% of patients. Median survival times were 16.2 and 18.7 months for radiotherapy alone and chemotherapy-surgery respectively (P = Ns), with no long-term improvement in survival seen with combined-modality treatment.
引用
收藏
页码：683 / 685
页数：3
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