Inflammation as a psychophysiological biomarker in chronic psychosocial stress

被引：304
作者：
Haensel, Alexander [1 ]
Hong, Suzi [2 ,3 ]
Camara, Rafael J. A. [1 ]
von Kaenel, Roland [1 ]
机构：
[1] Univ Hosp Bern, Dept Gen Internal Med, Div Psychosomat Med, CH-3010 Bern, Switzerland
[2] Univ Bern, CH-3010 Bern, Switzerland
[3] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA
来源：
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2010年 / 35卷 / 01期
关键词：
(I)nflammation; Psychosocial stress; Cardiovascular disease; Burnout; Life event stress; Socioeconomic status; Loneliness; Autonomic nervous system; Hypothalamus-pituitary-adrenal axis; C-REACTIVE PROTEIN; GLUCOCORTICOID-RECEPTOR-BETA; NF-KAPPA-B; SOCIOECONOMIC-STATUS; PSYCHOLOGICAL STRESS; OLDER-ADULTS; ANTIINFLAMMATORY CYTOKINES; MULTIPLE-SCLEROSIS; CAREGIVING STRESS; MAJOR DEPRESSION;
D O I：
10.1016/j.neubiorev.2009.12.012
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The measurement of inflammation by biomarkers not only documents clinically relevant infections but also offers an important tool to pin point potentially harmful effects of chronic psychosocial stressors. This article focuses firstly on basic biology of inflammation and lists main biomarkers currently used in psycho-physiologic research. In the second part, the effects of the hypothalamic-pituitary-adrenal (HPA) axis and the autonomic nervous system as pathways modulating stress-related inflammation are discussed. Furthermore, current evidence of how chronic psychosocial stressors are related to alterations in inflammatory activity is presented. In summary, job stress, low socioeconomic status, childhood adversities as well as life events, caregiver stress, and loneliness were all shown to exert effects on immunologic activity. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：115 / 121
页数：7
相关论文
共 94 条
[1]   Day-to-day dynamics of experience-cortisol associations in a population-based sample of older adults [J].
Adam, Emma K. ;
Hawkley, Louise C. ;
Kudielka, Brigitte M. ;
Cacioppo, John T. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (45) :17058-17063
[2]  
Adcock I M, 2000, Monaldi Arch Chest Dis, V55, P256
[3]   Transcription factor NF-κB -: A sensor for smoke and stress signals [J].
Ahn, KS ;
Aggarwal, BB .
NATURAL PRODUCTS AND MOLECULAR THERAPY, 2005, 1056 :218-233
[4]  
ALEXANDER N, 2009, PSYCHONEUROENDO 0430
[5]   Socioeconomic status and C-reactive protein levels in the US population: NHANES IV [J].
Alley, Dawn E. ;
Seeman, Teresa E. ;
Kim, Jung Ki ;
Karlamangla, Arun ;
Hu, Peifeng ;
Crimmins, Eileen M. .
BRAIN BEHAVIOR AND IMMUNITY, 2006, 20 (05) :498-504
[6]  
Arnason B G, 1988, Ann N Y Acad Sci, V540, P585, DOI 10.1111/j.1749-6632.1988.tb27181.x
[7]   Combination of caregiving stress and hormone replacement therapy is associated with prolonged platelet activation to acute stress among postmenopausal women [J].
Aschbacher, Kirstin ;
von Kaenel, Roland ;
Mills, Paul J. ;
Hong, Suzi ;
Roepke, Susan K. ;
Mausbach, Brent T. ;
Patterson, Thomas L. ;
Ziegler, Michael G. ;
Dimsdale, Joel E. ;
Ancoli-Israel, Sonia ;
Grant, Igor .
PSYCHOSOMATIC MEDICINE, 2007, 69 (09) :910-917
[8]   Anti-inflammatory actions of glucocorticoids: molecular mechanisms [J].
Barnes, PJ .
CLINICAL SCIENCE, 1998, 94 (06) :557-572
[9]   Cortisol dysregulation in school teachers in relation to burnout, vital exhaustion, and effort-reward-imbalance [J].
Bellingrath, Silja ;
Weigl, Tobias ;
Kudielka, Brigitte M. .
BIOLOGICAL PSYCHOLOGY, 2008, 78 (01) :104-113
[10]   A mechanism converting psychosocial stress into mononuclear cell activation [J].
Bierhaus, A ;
Wolf, J ;
Andrassy, M ;
Rohleder, N ;
Humpert, PM ;
Petrov, D ;
Ferstl, R ;
von Eynatten, M ;
Wendt, T ;
Rudofsky, G ;
Joswig, M ;
Morcos, M ;
Schwaninger, M ;
McEwen, B ;
Kirschbaum, C ;
Nawroth, PP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (04) :1920-1925
12345678910