Biodegradable π-Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics

被引：225

作者：

Li, Xiaozhen ^{[1
]}

Liu, Lu ^{[2
]}

Li, Shengliang ^{[1
]}

Wan, Yingpeng ^{[1
]}

Chen, Jia-Xiong ^{[1
,4
]}

Tian, Shuang ^{[1
]}

Huang, Zhongming ^{[1
]}

Xiao, Ya-Fang ^{[1
]}

Cui, Xiao ^{[1
]}

Xiang, Chengyan ^{[3
]}

Tan, Qinglong ^{[3
]}

Zhang, Xiao-Hong ^{[4
]}

Guo, Weisheng ^{[3
]}

Liang, Xing-Jie ^{[2
]}

Lee, Chun-Sing ^{[1
]}

机构：

[1] City Univ Hong Kong, Dept Chem, COSDAF, Kowloon, 83 Tat Chee Ave, Hong Kong 999077, Peoples R China

[2] Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol China, 11 First North Rd, Beijing 100190, Peoples R China

[3] Guangzhou Med Univ, Affiliated Hosp 2, State Key Lab Resp Dis, Translat Med Ctr, Guangzhou 510260, Guangdong, Peoples R China

[4] Soochow Univ, Joint Int Res Lab Carbon Based Funct Mat & Device, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat FUNSOM, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China

来源：

ACS NANO | 2019年 / 13卷 / 11期

关键词：

conjugated oligomer; nanoparticle; photothermal conversion efficiency; biodegradability; photothermal therapy; SEMICONDUCTING POLYMER NANOPARTICLES; CARBON NANOTUBES; THERAPY; NANOMATERIALS; ACTIVATION; GRAPHENE; OXIDE; DOTS;

D O I：

10.1021/acsnano.9b05383

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We developed a biodegradable photothermal therapeutic (PTT) agent, pi-conjugated oligomer nanoparticles (F8 -PEG NPs), for highly efficient cancer theranostics. By exploiting an oligomer with excellent nearinfrared (NIR) absorption, the nanoparticles show a high photothermal conversion efficiency (PCE) up to 82%, surpassing those of reported inorganic and organic PTT agents. In addition, the oligomer nanoparticles show excellent photostability and good biodegradability. The F8 -PEG NPs are also demonstrated to have excellent biosafety and PTT efficacy both in vitro and in vivo. This contribution not only proposes a promising oligomer-based PTT agent but also provides insight into developing highly efficient nanomaterials for cancer theranostics.

引用

页码：12901 / 12911

页数：11

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