Synthesis and Characterization of Preacinetobactin and 5-Phenyl Preacinetobactin

被引：2

作者：

Bray, Jean M. ^{[1
]}

Pierce, Scott ^{[1
]}

Angeles-Boza, Alfredo M. ^{[1
]}

Peczuh, Mark W. ^{[1
]}

机构：

[1] Univ Connecticut, Dept Chem, 55 N Eagleville Rd,U3060, Storrs, CT 06269 USA

来源：

MOLECULES | 2022年 / 27卷 / 12期

关键词：

acinetobactin; preacinetobactin; siderophore; synthesis; A; baumanii; ACINETOBACTER-BAUMANNII; SIDEROPHORE;

D O I：

10.3390/molecules27123688

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the first total synthesis of 5-phenyl preacinetobactin and its characterization. The route was developed for the synthesis of preacinetobactin, the siderophore critical to the Gram-negative pathogen A. baumannii. It leverages a C5-substituted benzaldehyde as a key starting material and should enable the synthesis of similar analogs. 5-Phenyl preacinetobactin binds iron in a manner analogous to the natural siderophore, but it did not rescue growth in a strain of A. baumannii unable to produce preacinetobactin.

引用

页数：13

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