Dose-Dependent Effects of Intravenous Mesenchymal Stem Cell Transplantation in Rats with Acute Focal Cerebral Ischemia

被引：3
作者：
Cherkashova, E. A. [1 ,2 ]
Namestnikova, D. D. [1 ,2 ]
Gubskiy, I. L. [1 ,2 ]
Revkova, V. A. [3 ]
Sukhinich, K. K. [4 ]
Mel'nikov, P. A. [5 ]
Chekhonin, V. P. [2 ,5 ]
Gubsky, L. V. [1 ,2 ]
Yarygin, K. N. [6 ,7 ]
机构：
[1] Fed Med Biol Agcy Russia, Fed Ctr Brain Res & Neurotechnol, Moscow, Russia
[2] Pirogov Russian Natl Res Med Univ, Minist Hlth Russian Federat, Moscow, Russia
[3] Fed Med Biol Agcy Russia, Fed Res Clin Ctr Specialized Types Med Care & Med, Moscow, Russia
[4] Russian Acad Sci, N K Koltsov Inst Dev Biol, Moscow, Russia
[5] VP Serbsky Natl Med Res Ctr Psychiat & Narcol, Minist Hlth Russian Federat, Moscow, Russia
[6] VN Orekhovich Res Inst Bio Med Chem, Moscow, Russia
[7] Russian Med Acad Continuous Profess Educ, Minist Hlth Russian Fed, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2022年 / 173卷 / 04期
关键词：
cell therapy; mesenchymal stem cells; ischemic stroke; model of middle cerebral artery occlusion; intravenous administration; ARTERY OCCLUSION; STROKE;
D O I：
10.1007/s10517-022-05573-5
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Intravenous transplantation of mesenchymal stem (stromal) cells (MSC) is a promising approach to the treatment of ischemic stroke. In the published reports of the already completed preclinical and clinical studies the dosages of transplanted MSC greatly vary. However, the optimal dosage has not been determined. The dose-dependent effect of intravenous MSC transplantation was studied, in rats with experimental cerebral infarction. To this end, 5x10(5) and 2x10(6) MSC were intravenously administered 24 h after modeling of acute focal ischemia followed by complex assessment of the therapeutic efficacy over 60 days. The rate and degree of the recovery of neurological functions in rats increased with increasing the dose of injected cells, which confirms the dose-dependent effect of intravenous MSC transplantation.
引用
收藏
页码：514 / 518
页数：5
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