Assessment of uric acid and lipid peroxidation in serum and urine after hypoxia-ischemia neonatal in rats

被引：10
作者：
Pimentel, V. C. [1 ,2 ]
Pinheiro, F. V. [1 ,2 ]
Kaefer, M. [1 ,2 ]
Moresco, R. N. [1 ,2 ]
Moretto, M. B. [1 ,2 ]
机构：
[1] Univ Fed Santa Maria, Hlth Sci Ctr, Postgrad Program Pharmaceut Sci, BR-97105900 Santa Maria, RS, Brazil
[2] Univ Fed Santa Maria, Dept Analises Clin & Toxicol, BR-97105900 Santa Maria, RS, Brazil
来源：
NEUROLOGICAL SCIENCES | 2011年 / 32卷 / 01期
关键词：
Hypoxic ischemia neonatal; Uric acid; Myeloperoxidase; Urinary lipid peroxidation; ADENOSINE-DEAMINASE ACTIVITY; BLOOD-BRAIN-BARRIER; OXIDATIVE STRESS; SUPEROXIDE-DISMUTASE; PERINATAL ASPHYXIA; BEHCETS-DISEASE; CEREBRAL-CORTEX; INJURY; DAMAGE; MALONDIALDEHYDE;
D O I：
10.1007/s10072-010-0393-3
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The aim of this study was to evaluate urinary uric acid (UA) and lipid peroxidation levels, plasma myeloperoxidase (MPO) and adenosine deaminase (ADA) activities, and serum UA in neonatal rats subjected to hypoxia-ischemia neonatal HI model. The relevance of the findings is the fact that urinary lipid peroxidation and UA levels were significantly higher in 8 days in HI group when compared with the control, returning to baseline levels 60 days after HI. Hence, being an indication of purinic degradation during these first days post-HI. Furthermore, the higher levels of malondialdehyde (MDA) in urine in this period may be related to inadequate scavenging abilities of the immature nervous system and being noninvasive it may suggest the use of urinary MDA measurement as a marker for lipid peroxidation after HI insult. In application terms, these findings can help develop therapeutic interventions as soon as 8 days after HI.
引用
收藏
页码：59 / 65
页数：7
相关论文
共 60 条
[1]  
Akisu M, 1998, ACTA PAEDIATR JAPON, V40, P78
[2]  
Al-Majed Abdulhakeem A., 2004, Research Communications in Molecular Pathology and Pharmacology, V115, P49
[3]   URIC-ACID PROVIDES AN ANTIOXIDANT DEFENSE IN HUMANS AGAINST OXIDANT-CAUSED AND RADICAL-CAUSED AGING AND CANCER - A HYPOTHESIS [J].
AMES, BN ;
CATHCART, R ;
SCHWIERS, E ;
HOCHSTEIN, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (11) :6858-6862
[4]  
Anju TR, 2009, INDIAN J BIOCHEM BIO, V46, P166
[5]   Child neurology in the 20th century [J].
Ashwal, S ;
Rust, R .
PEDIATRIC RESEARCH, 2003, 53 (02) :345-361
[6]   Male gender increases sensitivity to renal injury in response to cholesterol loading [J].
Attia, DM ;
Goldschmeding, R ;
Attia, MA ;
Boer, P ;
Koomans, HA ;
Joles, JA .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2003, 284 (04) :F718-F726
[7]   THE HALIDE-COMPLEXES OF MYELOPEROXIDASE AND THE MECHANISM OF THE HALOGENATION REACTIONS [J].
BAKKENIST, ARJ ;
DEBOER, JEG ;
PLAT, H ;
WEVER, R .
BIOCHIMICA ET BIOPHYSICA ACTA, 1980, 613 (02) :337-348
[8]   Can urinary excretion rate of malondialdehyde, uric acid and protein predict the severity and impending death in perinatal asphyxia? [J].
Banupriya, C. ;
Ratnakar ;
Doureradjou, P. ;
Mondal, N. ;
Vishnu, Bhat ;
Koner, B. C. .
CLINICAL BIOCHEMISTRY, 2008, 41 (12) :968-973
[9]   A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia - A preliminary report [J].
Bar-Or, D ;
Lau, E ;
Winkler, JV .
JOURNAL OF EMERGENCY MEDICINE, 2000, 19 (04) :311-315
[10]   Correlation between Apgar score and urinary uric acid to creatinine ratio in perinatal asphyxia [J].
Basu P. ;
Som S. ;
Choudhuri N. ;
Das H. .
Indian Journal of Clinical Biochemistry, 2008, 23 (4) :361-364
123456