Can Ultrasound Elastography Help Better Manage Mammographic BI-RADS Category 4 Breast Lesions?

被引：3

作者：

Gu, Yang ^{[1
]}

Tian, Jiawei ^{[2
]}

Ran, Haitao ^{[3
,4
]}

Ren, Weidong ^{[5
]}

Chang, Cai ^{[6
,7
]}

Yuan, Jianjun ^{[8
]}

Kang, Chunsong ^{[9
]}

Deng, Youbin ^{[10
]}

Wang, Hui ^{[11
]}

Luo, Baoming ^{[12
]}

Guo, Shenglan ^{[13
]}

Zhou, Qi ^{[14
]}

Xue, Ensheng ^{[15
]}

Zhan, Weiwei ^{[16
]}

Zhou, Qing ^{[17
]}

Li, Jie ^{[18
]}

Zhou, Ping ^{[19
]}

Zhang, Chunquan ^{[20
]}

Chen, Man ^{[21
]}

Gu, Ying ^{[22
]}

Xu, Jinfeng ^{[23
]}

Chen, Wu ^{[24
]}

Zhang, Yuhong ^{[25
]}

Li, Jianchu ^{[1
]}

Wang, Hongyan ^{[1
]}

Jiang, Yuxin ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Ultrasound, 1 Shuai Fu Yuan, Beijing 100730, Peoples R China

[2] Harbin Med Univ, Dept Ultrasound, Affiliated Hosp 2, Harbin, Peoples R China

[3] Chongqing Med Univ, Dept Ultrasound, Affiliated Hosp 2, Chongqing, Peoples R China

[4] Chongqing Key Lab Ultrasound Mol Imaging, Chongqing, Peoples R China

[5] China Med Univ, Dept Ultrasound, Shengjing Hosp, Shenyang, Peoples R China

[6] Fudan Univ, Shanghai Canc Ctr, Dept Med Ultrasound, Shanghai, Peoples R China

[7] Fudan Univ, Dept Oncol, Shanghai Med Coll, Shanghai, Peoples R China

[8] Henan Prov Peoples Hosp, Dept Ultrasonog, Zhengzhou, Peoples R China

[9] Shanxi Acad Med Sci, Shanxi Bethune Hosp, Dept Ultrasound, Taiyuan, Peoples R China

[10] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Med Ultrasound, Tongji Med Coll, Wuhan, Peoples R China

[11] Jilin Univ, Dept Ultrasound, China Japan Union Hosp, Changchun, Peoples R China

[12] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Ultrasound, Guangzhou, Peoples R China

[13] Guangxi Med Univ, Dept Ultrasonog, Affiliated Hosp 1, Nanning, Peoples R China

[14] Xi An Jiao Tong Univ, Affiliated Hosp 2, Sch Med, Dept Med Ultrasound, Xian, Peoples R China

[15] Fujian Med Univ, Fujian Inst Ultrasound Med, Dept Ultrasound, Union Hosp, Fuzhou, Peoples R China

[16] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Ultrasound, Shanghai, Peoples R China

[17] Wuhan Univ, Dept Ultrasonog, Renmin Hosp, Wuhan, Peoples R China

[18] Shandong Univ, Qilu Hosp, Dept Ultrasound, Jinan, Peoples R China

[19] Cent South Univ, Dept Ultrasound, Xiangya Hosp 3, Changsha, Peoples R China

[20] Nanchang Univ, Dept Ultrasound, Affiliated Hosp 2, Nanchang, Jiangxi, Peoples R China

[21] Shanghai Jiao Tong Univ, Tongren Hosp, Dept Ultrasound Med, Sch Med, Shanghai, Peoples R China

[22] Guizhou Med Univ, Dept Ultrasonog, Affiliated Hosp, Guiyang, Peoples R China

[23] Jinan Univ, Shenzhen Peoples Hosp, Dept Ultrasound, Clin Med Coll 2, Shenzhen, Peoples R China

[24] Shanxi Med Univ, Dept Ultrasound, Hosp 1, Taiyuan, Peoples R China

[25] Dalian Med Univ, Dept Ultrasound, Hosp 2, Dalian, Peoples R China

来源：

CLINICAL BREAST CANCER | 2022年 / 22卷 / 04期

基金：

北京市自然科学基金;

关键词：

Breast classification; Breast neoplasms; Mammography; Ultrasonography; Diagnostic performance; SCREENING MAMMOGRAPHY; US ELASTOGRAPHY; CANCER; VARIABILITY; DIFFERENTIATION; DIAGNOSIS; SYMPTOMS; WOMEN;

D O I：

10.1016/j.clbc.2021.10.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We assessed the performance of conventional ultrasound (US) combined with strain elastography (SE) in the Breast Imaging Reporting and Data System (BI-RADS) category 4 lesions on mammography. A total of 751 women with 751 breast lesions classified as mammographic BI-RADS category 4 were included. Conventional US combined with SE helped increase the PPV and had the potential to avoid unnecessary biopsies of BI-RADS category 4 lesions detected on mammography. Background: To assess the performance of conventional ultrasound (US) combined with strain elastography (SE) in the Breast Imaging Reporting and Data System (BI-RADS) category 4 lesions on mammography. Materials and Methods: Women with breast lesions identified as having mammography BI-RADS 4 lesions and underwent US examination were included in China. US features and US BI-RADS assessment were recorded in real-time and prospectively reported. The pathological result was referred to as the gold standard. The performance of US in the mammographic BI-RADS category 4 lesions was evaluated. Diagnostic performances of US BI-RADS, SE and combined both were compared. Results: A total of 751 women with 751 breast lesions classified as mammographic BI-RADS category 4 were included. For mammographic findings, 530 (70.6%) were true positive and 221 (29.4%) were false positive. Conventional US achieved higher positive predictive value (PPV) than mammography (78.5% vs. 70.6%, P=.001). The specificity increased from 34.4% to 47.1% (P < . .001) without any loss in sensitivity and the PPV increased to 81.9% (P = .122) when conventional US was used in combination with SE. For conventional US combined with SE, it led to a correct diagnosis of no breast cancer in 104 of the 221 false-positive findings (47.1%) and achieved higher PPV than mammography regardless of patient age and lesion size. Conclusion: Conventional US combined with SE is a helpful tool for the noninvasive examination of breast lesions classified as BI-RADS category 4 on mammography. It helped increase the PPV and had the potential to avoid unnecessary biopsies of BI-RADS category 4 lesions detected on mammography. (C) 2021 Elsevier Inc. All rights reserved.

引用

页码：E407 / E416

页数：10

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