Effects of Natural Chalcone-Tannin Hybrids Protecting Mesenchymal Stem Cells against ROS-mediated Oxidative Damage and Indexes for Antioxidant Mechanisms

被引：10
|
作者：
Li, Xican [1 ]
Liu, Jingjing [1 ]
Zhao, Zhong-xiang [1 ]
Wang, Tingting [1 ]
Lin, Jian [2 ]
Chen, Dongfeng [2 ]
机构：
[1] Guangzhou Univ Chinese Med, Sch Chinese Herbal Med, Guangzhou 510006, Guangdong, Peoples R China
[2] Guangzhou Univ Chinese Med, Sch Basic Med Sci, Guangzhou 510006, Guangdong, Peoples R China
来源：
CHEMISTRY LETTERS | 2016年 / 45卷 / 07期
关键词：
Chalcone hybrid; Radical scavenging; Antioxidant mechanism; AGENTS; DESIGN; ASSAY;
D O I：
10.1246/cl.160177
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
As antioxidants and potential beneficial agents in cell transplantation, natural chalcone-tannin hybrids can protect mesenchymal stem cells against ROS-mediated damage. In their antioxidant abilities, galloyl moiety, 4-OH, and 2'-OH present antioxidant indexes of 0.58:0.13:0.29. The galloyl moiety enhances antioxidant levels of chalcone-tannin hybrids. Their antioxidant mechanisms may include Fe2+-chelating and direct radical scavenging, which comprises at least one electron transfer (ET). The Fe2+-chelating and ET may mainly occur in the galloyl moiety, while 4-OH without H-bonding interference prefers to donate H atom.
引用
收藏
页码：743 / 745
页数：3
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