Temporal order memory differences in Alzheimer's disease and vascular dementia

被引：18

作者：

Hampstead, Benjamin M. ^{[1
,2
]}

Libon, David J. ^{[3
]}

Moelter, Stephen T. ^{[4
]}

Swirsky-Sacchetti, Thomas ^{[5
]}

Scheffer, Ludo ^{[6
]}

Platek, Steven M. ^{[7
]}

Chute, Douglas ^{[6
]}

机构：

[1] Atlanta VA Med Ctr, VA RR&D Ctr Excellence, Decatur, GA USA

[2] Emory Univ, Sch Med, Dept Rehabil Med, Atlanta, GA USA

[3] Drexel Univ, Coll Med, Dept Neurol, Philadelphia, PA 19104 USA

[4] Univ Sci Philadelphia, Hlth Psychol Program, Philadelphia, PA USA

[5] Thomas Jefferson Univ, Jefferson Med Coll, Dept Psychiat & Human Behav, Philadelphia, PA 19107 USA

[6] Drexel Univ, Philadelphia, PA 19104 USA

[7] Georgia Gwinnett Coll, Lawrenceville, GA USA

来源：

JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY | 2010年 / 32卷 / 06期

关键词：

Small vessel ischemic disease; Sequential memory; Working memory; Mild cognitive impairment; Leukoaraiosis; MILD COGNITIVE IMPAIRMENT; MEDIAL PREFRONTAL CORTEX; VERBAL WORKING-MEMORY; RECOGNITION MEMORY; BINSWANGERS-DISEASE; PARKINSONS-DISEASE; BRAIN; LEUKOARAIOSIS; VALIDATION; MECHANISMS;

D O I：

10.1080/13803390903418918

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Determining the order of events is essential for accurate memory recollection: an ability previously linked to both frontal and medial temporal functioning. Frontal-subcortical and medial temporal dysfunction typify vascular dementia (VaD) and Alzheimer's disease (AD), respectively. Therefore, we assessed patients' ordering abilities using a novel sequencing task that progressively increased memory load. VaD patients made more errors and selected more previously encountered stimuli than did AD. Curve analysis revealed a general decline in ordering for VaD whereas error production in AD is more dependent on memory load. These findings generally support the role of frontal-subcortical functioning in temporal order memory.

引用

页码：645 / 654

页数：10

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