Preparation of optically active 2-(trifluoromethyl)alkan-1-ols by catalytic asymmetric hydrogenation

被引：0

作者：

Iseki, K

Kuroki, Y

Nagai, T

Kobayashi, Y

机构：

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1996年 / 44卷 / 03期

关键词：

asymmetric hydrogenation; asymmetric synthesis; chiral fluorinated compound; 2-(trifluoromethyl)alkan-1-ol; 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The hydrogenation of (E)-2-(trifluoromethyl)alk-2-en-1-ols catalyzed by Ru-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (Ru-BINAP) and Rh-BINAP was carried out with good enantiomeric excess (71-83% ee). Ru-BINAP-catalyzed hydrogenation converted 2-(trifluoromethyl)acrylic acid to the corresponding saturated acid whose esterification and reduction provided optically active 2-(trifluoromethyl)propan-1-ol in 80% ee.

引用

页码：477 / 480

页数：4

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