Studies on Synthesis of Novel Pyrido[2,3-d] pyrimidine Derivatives and Their Anticancer Activity

被引：3

作者：

Banda, Veeraswamy ^{[1
]}

Jitender, Dev Gaddameedi ^{[1
]}

Santhosh, Kumar Gautham ^{[1
]}

Sambasiva, Rao Pillalamarri ^{[1
]}

Chavva, Kurumurthy ^{[1
]}

Rajesh, Pamanji ^{[2
]}

Venkateswara, Rao Janapala ^{[2
]}

Banda, Narsaiah ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Fluoroorgan Div, Hyderabad 500007, Telangana, India

[2] Indian Inst Chem Technol, Biol Div, Hyderabad 500007, Telangana, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2018年 / 55卷 / 11期

关键词：

ROUTE;

D O I：

10.1002/jhet.3307

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel pyrido[2,3-d]pyrimidine derivatives 7 were prepared starting from 2-amino nicotinonitrile 3 via Grignard's reaction followed by cyclization and nucleophilic substitution. All the products 7 were screened against four human cancer cell lines. Compounds 7b, 7e, 7m, and 7o that showed good activity against all the cell lines have been identified.

引用

页码：2538 / 2544

页数：7

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