PURPOSE: To report a case of a solitary, nonreactive choroidal tuberculoma in a patient with acquired immune deficiency syndrome (AIDS). METHOD: Case Report. RESULTS: A 26-year-old male patient with AIDS and systemic tuberculosis was found to have a solitary 1.5-disc-diameter elevated mass just superior and temporal to the optic disc. There was no associated inflammation, exudate, hemorrhage, or serous retinal detachment. Fluorescein angiography showed late hyperfluorescence in a staining pattern. The mass quickly regressed with antituberculosis therapy. CONCLUSIONS: Choroidal tuberculoma can present with little associated inflammation or retinal change in a patient with AIDS. The clinical history and knowledge of opportunistic choroidal infections in patients with AIDS helps to make the diagnosis. (Am J Ophthalmol 2001;131:138-140. (C) 2001 by Elsevier Science Inc. All rights reserved.).