Neural Control and Modulation of Thirst, Sodium Appetite, and Hunger

被引：86

作者：

Augustine, Vineet ^{[1
,2
]}

Lee, Sangjun ^{[1
]}

Oka, Yuki ^{[1
]}

机构：

[1] CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA

[2] Scripps Res Inst, Dept Neurosci, La Jolla, CA 92037 USA

来源：

CELL | 2020年 / 180卷 / 01期

关键词：

SALT APPETITE; EXPRESSING NEURONS; UNDERLYING THIRST; PREOPTIC NEURONS; SENSORY NEURONS; BRAIN; CIRCUIT; WATER; FOOD; DRINKING;

D O I：

10.1016/j.cell.2019.11.040

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The function of central appetite neurons is instructing animals to ingest specific nutrient factors that the body needs. Emerging evidence suggests that individual appetite circuits for major nutrients-water, sodium, and food-operate on unique driving and quenching mechanisms. This review focuses on two aspects of appetite regulation. First, we describe the temporal relationship between appetite neuron activity and consumption behaviors. Second, we summarize ingestion-related satiation signals that differentially quench individual appetite circuits. We further discuss how distinct appetite and satiation systems for each factor may contribute to nutrient homeostasis from the functional and evolutional perspectives.

引用

页码：25 / 32

页数：8

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