Lectins: an effective tool for screening of potential cancer biomarkers

被引：80
作者：
Hashim, Onn Haji [1 ,2 ]
Jayapalan, Jaime Jacqueline [2 ]
Lee, Cheng-Siang [1 ]
机构：
[1] Univ Malaya, Fac Med, Dept Mol Med, Kuala Lumpur, Malaysia
[2] Univ Malaya, Fac Med, Ctr Prote Res, Kuala Lumpur, Malaysia
来源：
PEERJ | 2017年 / 5卷
关键词：
Cancer; Lectin; Biomarker; Glycan; Proteomics; Glycosylation; 2-DIMENSIONAL GEL-ELECTROPHORESIS; CARBOHYDRATE-BINDING SPECIFICITY; BENIGN PROSTATIC HYPERPLASIA; ALPHA-TRYPSIN INHIBITOR; HIGH-ABUNDANCE PROTEINS; WHEAT-GERM-AGGLUTININ; HUMAN BREAST-CANCER; COLORECTAL-CANCER; MANNOSE-BINDING; PLANT-LECTINS;
D O I：
10.7717/peerj.3784
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In recent years, the use of lectins for screening of potential biomarkers has gained increased importance in cancer research, given the development in glycobiology that highlights altered structural changes of glycans in cancer associated processes,Lectins, having the properties of recognizing carbohydrate moieties of glycoconiugates, have become an effective tool for detection of new cancer biomarkers in complex bodily fluids and tissues. The specificity of lectins provides an added advantage of selecting peptides that are differently glycosylated and aberrantly expressed in cancer patients, many of which are not possibly detected using conventional methods because of their low abundance in bodily fluids. When coupled with mass spectrometry, research utilizing lectins, which are mainly from plants and fungi, has led to identification of numerous potential cancer biomarkers that may be used in the future. This article reviews lectin-based methods that are commonly adopted in cancer biomarker discovery research.
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页数：30
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