Fibrous materials are of great interest in the development of tissue regenerative matrix. However, synthesis of inorganic fibrous microspheres as cell carriers is a great challenge. In this study, we for the first time report on the synthesis of novel hierarchical and flower-like TiO2 nanowire (NW) microspheres as biocompatible cell carriers. TiO2 NW microspheres were synthesized through in situ alkali hydrothermal treatment of the TiO2 nanoparticle (NP) microspheres and their microstructure, formation mechanism and in vitro biocompatibility were evaluated. SEM observations show that the resulting TiO2 NW microspheres were constructed by a large number of NWs with the diameter of 10-20 nm and exhibited a flower-like and hierarchical morphology with the diameter of 400-600 mu m. XRD patterns indicate that TiO2 NW microspheres were constructed by both rutile and anatase phase of TiO2. FT-IR spectra reveal that Ti-O-Ti bonds were involved in TiO2 NW microspheres. In vitro biocompatibility was evaluated by seeding the fibroblast L929 cells on the microspheres. A conventional MTT assay quantitatively indicates that the TiO2 NW microspheres favored adhesion and proliferation of cells and were biocompatible, while SEM observations qualitatively confirmed that the cells were well grown on the surface of TiO2 NW microspheres. Thus, the as-synthesized TiO2 NW microspheres would be applicable to novel and biocompatible cell carriers.
机构:
Univ Tehran, Fac New Sci & Technol, Dept Life Sci Engn, Div Biomed Engn, Tehran 143951561, IranUniv Tehran, Fac New Sci & Technol, Dept Life Sci Engn, Div Biomed Engn, Tehran 143951561, Iran
Khakbiz, Mehrdad
;
Nezafati, Nader
论文数: 0引用数: 0
h-index: 0
机构:
Mat & Energy Res Ctr, Nanotechnol & Adv Mat Dept, Biomat Res Grp, Karaj, IranUniv Tehran, Fac New Sci & Technol, Dept Life Sci Engn, Div Biomed Engn, Tehran 143951561, Iran
机构:
ESTV, Dep Eng Mecan & Gestao Ind, P-3504510 Viseu, Portugal
Inst Engn Biomed INEB, Div Biomat, P-4150180 Oporto, Portugal
Univ Porto, Fac Engn, Dep Eng Met & Mat, P-4200465 Oporto, PortugalESTV, Dep Eng Mecan & Gestao Ind, P-3504510 Viseu, Portugal
Oliveira, Serafim M.
;
Barrias, Cristina C.
论文数: 0引用数: 0
h-index: 0
机构:
Inst Engn Biomed INEB, Div Biomat, P-4150180 Oporto, PortugalESTV, Dep Eng Mecan & Gestao Ind, P-3504510 Viseu, Portugal
Barrias, Cristina C.
;
Almeida, Isabel F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Porto, Fac Farm, Dept Tecnol Farmaceut, P-4050047 Oporto, PortugalESTV, Dep Eng Mecan & Gestao Ind, P-3504510 Viseu, Portugal
Almeida, Isabel F.
;
Costa, Paulo C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Porto, Fac Farm, Dept Tecnol Farmaceut, P-4050047 Oporto, PortugalESTV, Dep Eng Mecan & Gestao Ind, P-3504510 Viseu, Portugal
Costa, Paulo C.
;
Ferreira, Maria R. Pena
论文数: 0引用数: 0
h-index: 0
机构:
Univ Porto, Fac Farm, Dept Tecnol Farmaceut, P-4050047 Oporto, PortugalESTV, Dep Eng Mecan & Gestao Ind, P-3504510 Viseu, Portugal
Ferreira, Maria R. Pena
;
Bahia, Maria F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Porto, Fac Farm, Dept Tecnol Farmaceut, P-4050047 Oporto, PortugalESTV, Dep Eng Mecan & Gestao Ind, P-3504510 Viseu, Portugal
Bahia, Maria F.
;
Barbosa, Mario A.
论文数: 0引用数: 0
h-index: 0
机构:
Inst Engn Biomed INEB, Div Biomat, P-4150180 Oporto, Portugal
Univ Porto, Fac Engn, Dep Eng Met & Mat, P-4200465 Oporto, PortugalESTV, Dep Eng Mecan & Gestao Ind, P-3504510 Viseu, Portugal
机构:
Peking Univ, Dept Biomed Engn, Beijing 100871, Peoples R ChinaGeorgia Inst Technol, Inst Bioengn & Biosci, Atlanta, GA 30332 USA
Wang, Xiaokun
;
Gittens, Rolando A.
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Inst Technol, Inst Bioengn & Biosci, Atlanta, GA 30332 USA
Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USAGeorgia Inst Technol, Inst Bioengn & Biosci, Atlanta, GA 30332 USA
Gittens, Rolando A.
;
Song, Rosemary
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Tech, Wallace H Coulter Dept Biomed Engn, Atlanta, GA USA
Emory Univ, Georgia Inst Technol, Atlanta, GA 30322 USAGeorgia Inst Technol, Inst Bioengn & Biosci, Atlanta, GA 30332 USA
Song, Rosemary
;
Tannenbaum, Rina
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USAGeorgia Inst Technol, Inst Bioengn & Biosci, Atlanta, GA 30332 USA
Tannenbaum, Rina
;
论文数: 引用数:
h-index:
机构:
Olivares-Navarrete, Rene
;
Schwartz, Zvi
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Inst Technol, Inst Bioengn & Biosci, Atlanta, GA 30332 USA
Georgia Tech, Wallace H Coulter Dept Biomed Engn, Atlanta, GA USA
Emory Univ, Georgia Inst Technol, Atlanta, GA 30322 USAGeorgia Inst Technol, Inst Bioengn & Biosci, Atlanta, GA 30332 USA
Schwartz, Zvi
;
Chen, Haifeng
论文数: 0引用数: 0
h-index: 0
机构:
Peking Univ, Dept Biomed Engn, Beijing 100871, Peoples R ChinaGeorgia Inst Technol, Inst Bioengn & Biosci, Atlanta, GA 30332 USA
Chen, Haifeng
;
Boyan, Barbara D.
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Inst Technol, Inst Bioengn & Biosci, Atlanta, GA 30332 USA
Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA
Georgia Tech, Wallace H Coulter Dept Biomed Engn, Atlanta, GA USA
Emory Univ, Georgia Inst Technol, Atlanta, GA 30322 USAGeorgia Inst Technol, Inst Bioengn & Biosci, Atlanta, GA 30332 USA
机构:
Univ Nacl Litoral, Inst Desarrollo Tecnol Ind Quim, RA-3000 Santa Fe, Argentina
Consejo Nacl Invest Cient & Tecn, RA-3000 Santa Fe, Argentina
Univ Nacl Litoral, Fac Bioquim & Ciencias Biol, RA-3000 Santa Fe, ArgentinaUniv Nacl Litoral, Inst Desarrollo Tecnol Ind Quim, RA-3000 Santa Fe, Argentina
Zacarias, Silvia M.
;
Satuf, Maria L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nacl Litoral, Inst Desarrollo Tecnol Ind Quim, RA-3000 Santa Fe, Argentina
Consejo Nacl Invest Cient & Tecn, RA-3000 Santa Fe, ArgentinaUniv Nacl Litoral, Inst Desarrollo Tecnol Ind Quim, RA-3000 Santa Fe, Argentina
Satuf, Maria L.
;
Vaccari, Maria C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nacl Litoral, Fac Bioquim & Ciencias Biol, RA-3000 Santa Fe, ArgentinaUniv Nacl Litoral, Inst Desarrollo Tecnol Ind Quim, RA-3000 Santa Fe, Argentina
Vaccari, Maria C.
;
Alfano, Orlando M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nacl Litoral, Inst Desarrollo Tecnol Ind Quim, RA-3000 Santa Fe, Argentina
Consejo Nacl Invest Cient & Tecn, RA-3000 Santa Fe, ArgentinaUniv Nacl Litoral, Inst Desarrollo Tecnol Ind Quim, RA-3000 Santa Fe, Argentina
机构:
Univ Tehran, Fac New Sci & Technol, Dept Life Sci Engn, Div Biomed Engn, Tehran 143951561, IranUniv Tehran, Fac New Sci & Technol, Dept Life Sci Engn, Div Biomed Engn, Tehran 143951561, Iran
Khakbiz, Mehrdad
;
Nezafati, Nader
论文数: 0引用数: 0
h-index: 0
机构:
Mat & Energy Res Ctr, Nanotechnol & Adv Mat Dept, Biomat Res Grp, Karaj, IranUniv Tehran, Fac New Sci & Technol, Dept Life Sci Engn, Div Biomed Engn, Tehran 143951561, Iran
机构:
ESTV, Dep Eng Mecan & Gestao Ind, P-3504510 Viseu, Portugal
Inst Engn Biomed INEB, Div Biomat, P-4150180 Oporto, Portugal
Univ Porto, Fac Engn, Dep Eng Met & Mat, P-4200465 Oporto, PortugalESTV, Dep Eng Mecan & Gestao Ind, P-3504510 Viseu, Portugal
Oliveira, Serafim M.
;
Barrias, Cristina C.
论文数: 0引用数: 0
h-index: 0
机构:
Inst Engn Biomed INEB, Div Biomat, P-4150180 Oporto, PortugalESTV, Dep Eng Mecan & Gestao Ind, P-3504510 Viseu, Portugal
Barrias, Cristina C.
;
Almeida, Isabel F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Porto, Fac Farm, Dept Tecnol Farmaceut, P-4050047 Oporto, PortugalESTV, Dep Eng Mecan & Gestao Ind, P-3504510 Viseu, Portugal
Almeida, Isabel F.
;
Costa, Paulo C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Porto, Fac Farm, Dept Tecnol Farmaceut, P-4050047 Oporto, PortugalESTV, Dep Eng Mecan & Gestao Ind, P-3504510 Viseu, Portugal
Costa, Paulo C.
;
Ferreira, Maria R. Pena
论文数: 0引用数: 0
h-index: 0
机构:
Univ Porto, Fac Farm, Dept Tecnol Farmaceut, P-4050047 Oporto, PortugalESTV, Dep Eng Mecan & Gestao Ind, P-3504510 Viseu, Portugal
Ferreira, Maria R. Pena
;
Bahia, Maria F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Porto, Fac Farm, Dept Tecnol Farmaceut, P-4050047 Oporto, PortugalESTV, Dep Eng Mecan & Gestao Ind, P-3504510 Viseu, Portugal
Bahia, Maria F.
;
Barbosa, Mario A.
论文数: 0引用数: 0
h-index: 0
机构:
Inst Engn Biomed INEB, Div Biomat, P-4150180 Oporto, Portugal
Univ Porto, Fac Engn, Dep Eng Met & Mat, P-4200465 Oporto, PortugalESTV, Dep Eng Mecan & Gestao Ind, P-3504510 Viseu, Portugal
机构:
Peking Univ, Dept Biomed Engn, Beijing 100871, Peoples R ChinaGeorgia Inst Technol, Inst Bioengn & Biosci, Atlanta, GA 30332 USA
Wang, Xiaokun
;
Gittens, Rolando A.
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Inst Technol, Inst Bioengn & Biosci, Atlanta, GA 30332 USA
Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USAGeorgia Inst Technol, Inst Bioengn & Biosci, Atlanta, GA 30332 USA
Gittens, Rolando A.
;
Song, Rosemary
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Tech, Wallace H Coulter Dept Biomed Engn, Atlanta, GA USA
Emory Univ, Georgia Inst Technol, Atlanta, GA 30322 USAGeorgia Inst Technol, Inst Bioengn & Biosci, Atlanta, GA 30332 USA
Song, Rosemary
;
Tannenbaum, Rina
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USAGeorgia Inst Technol, Inst Bioengn & Biosci, Atlanta, GA 30332 USA
Tannenbaum, Rina
;
论文数: 引用数:
h-index:
机构:
Olivares-Navarrete, Rene
;
Schwartz, Zvi
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Inst Technol, Inst Bioengn & Biosci, Atlanta, GA 30332 USA
Georgia Tech, Wallace H Coulter Dept Biomed Engn, Atlanta, GA USA
Emory Univ, Georgia Inst Technol, Atlanta, GA 30322 USAGeorgia Inst Technol, Inst Bioengn & Biosci, Atlanta, GA 30332 USA
Schwartz, Zvi
;
Chen, Haifeng
论文数: 0引用数: 0
h-index: 0
机构:
Peking Univ, Dept Biomed Engn, Beijing 100871, Peoples R ChinaGeorgia Inst Technol, Inst Bioengn & Biosci, Atlanta, GA 30332 USA
Chen, Haifeng
;
Boyan, Barbara D.
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Inst Technol, Inst Bioengn & Biosci, Atlanta, GA 30332 USA
Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA
Georgia Tech, Wallace H Coulter Dept Biomed Engn, Atlanta, GA USA
Emory Univ, Georgia Inst Technol, Atlanta, GA 30322 USAGeorgia Inst Technol, Inst Bioengn & Biosci, Atlanta, GA 30332 USA
机构:
Univ Nacl Litoral, Inst Desarrollo Tecnol Ind Quim, RA-3000 Santa Fe, Argentina
Consejo Nacl Invest Cient & Tecn, RA-3000 Santa Fe, Argentina
Univ Nacl Litoral, Fac Bioquim & Ciencias Biol, RA-3000 Santa Fe, ArgentinaUniv Nacl Litoral, Inst Desarrollo Tecnol Ind Quim, RA-3000 Santa Fe, Argentina
Zacarias, Silvia M.
;
Satuf, Maria L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nacl Litoral, Inst Desarrollo Tecnol Ind Quim, RA-3000 Santa Fe, Argentina
Consejo Nacl Invest Cient & Tecn, RA-3000 Santa Fe, ArgentinaUniv Nacl Litoral, Inst Desarrollo Tecnol Ind Quim, RA-3000 Santa Fe, Argentina
Satuf, Maria L.
;
Vaccari, Maria C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nacl Litoral, Fac Bioquim & Ciencias Biol, RA-3000 Santa Fe, ArgentinaUniv Nacl Litoral, Inst Desarrollo Tecnol Ind Quim, RA-3000 Santa Fe, Argentina
Vaccari, Maria C.
;
Alfano, Orlando M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nacl Litoral, Inst Desarrollo Tecnol Ind Quim, RA-3000 Santa Fe, Argentina
Consejo Nacl Invest Cient & Tecn, RA-3000 Santa Fe, ArgentinaUniv Nacl Litoral, Inst Desarrollo Tecnol Ind Quim, RA-3000 Santa Fe, Argentina