Light-Induced Control of Protein Trans location by the SecYEG Complex

被引：45

作者：

Bonardi, Francesco ^{[1
,2
]}

London, Gabor ^{[3
,4
]}

Nouwen, Nico ^{[5
]}

Feringa, Ben L. ^{[3
,4
]}

Driessen, Arnold J. M. ^{[1
,2
]}

机构：

[1] Groningen Biomol Sci & Biotechnol Inst, NL-9751 NN Haren, Netherlands

[2] Zernike Inst Adv Mat, NL-9751 NN Haren, Netherlands

[3] Univ Groningen, Stratingh Inst Chem, NL-9747 AG Groningen, Netherlands

[4] Univ Groningen, Zernike Inst Adv Mat, NL-9747 AG Groningen, Netherlands

[5] Lab Symbioses Trop & Mediterraneennes, F-34398 Montpellier 5, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 40期

关键词：

azobenzenes; photoisomerization; proteins; supramolecular chemistry; translocation; ION CHANNELS; TRANSLOCATION; PEPTIDE; MEMBRANE; RECEPTOR;

D O I：

10.1002/anie.201002243

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Please close the pore! An organochemical photoswitch was introduced into two transmembrane segments that comprise the lateral gate of the bacterial-membrane-embedded protein-conducting pore. Reversible switching of the azobenzene between the trans and cis configurations by irradiation with visible and UV light enforced the opening and closure of the protein-conducting pore (see scheme). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7234 / 7238

页数：5

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