Reshaping drug development using 3D printing

被引:184
作者
Awad, Atheer [1 ]
Trenfield, Sarah J. [1 ]
Goyanes, Alvaro [2 ]
Gaisford, Simon [1 ,2 ]
Basit, Abdul W. [1 ,2 ]
机构
[1] UCL, UCL Sch Pharm, 29-39 Brunswick Sq, London WC1N 1AX, England
[2] FabRx Ltd, 3 Romney Rd, Ashford TN24 0RW, Kent, England
基金
英国工程与自然科学研究理事会;
关键词
INNOVATIVE APPROACH; DOSAGE FORMS; RELEASE; DELIVERY; TABLETS; DEVICES; REACTIONWARE; COMBINATION; FABRICATION; PRODUCTS;
D O I
10.1016/j.drudis.2018.05.025
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The pharmaceutical industry stands on the brink of a revolution, calling for the recognition and embracement of novel techniques. 3D printing (3DP) is forecast to reshape the way in which drugs are designed, manufactured, and used. Although a clear trend towards personalised fabrication is perceived, here we accentuate the merits and shortcomings of each technology, providing insights into aspects such as the efficiency of production, global supply, and logistics. Contemporary opportunities for 3DP in drug discovery and pharmaceutical development and manufacturing are unveiled, offering a forward looking view on its potential uses as a digitised tool for personalised dispensing of drugs.
引用
收藏
页码:1547 / 1555
页数:9
相关论文
共 60 条
[1]   Emergence of 3D Printed Dosage Forms: Opportunities and Challenges [J].
Alhnan, Mohamed A. ;
Okwuosa, Tochukwu C. ;
Sadia, Muzna ;
Wan, Ka-Wai ;
Ahmed, Waqar ;
Arafat, Basel .
PHARMACEUTICAL RESEARCH, 2016, 33 (08) :1817-1832
[2]  
[Anonymous], 2015, LANCET, V385, P746, DOI 10.1016/S0140-6736(15)60420-2
[3]  
[Anonymous], TNO IMPACT 3D PRINTI
[4]  
[Anonymous], ADD MAN
[5]  
[Anonymous], 2018, CAMBRIDGE INDEPENDEN
[6]  
[Anonymous], INJECTION MOLDING MA
[7]  
[Anonymous], 3D PRINT COMP
[8]  
Astm Iso., 2015, ASTM52900 15 STANDAR
[9]  
Atkeson A., 2001, TRANSITION NEW EC 2
[10]  
Barnatt C., 2016, 3D printing