Involvement of progranulin (PGRN) in the pathogenesis and prognosis of breast cancer

被引：17

作者：

Purrahman, Daryush ^{[1
]}

Mahmoudian-Sani, Mohammad-Reza ^{[1
,2
]}

Saki, Najmaldin ^{[1
]}

Wojdasiewicz, Piotr ^{[3
]}

Kurkowska-Jastrzebska, Iwona ^{[4
]}

Poniatowski, Lukasz A. ^{[5
,6
]}

机构：

[1] Ahvaz Jundishapur Univ Med Sci, Thalassemia & Hemoglobinopathy Res Ctr, Hlth Res Inst, Ahvaz, Iran

[2] Ahvaz Jundishapur Univ Med Sci, Golestan Hosp, Clin Res Dev Unit, Ahvaz, Iran

[3] Med Univ Warsaw, Fac Hlth Sci, Dept Biophys Physiol & Pathophysiol, Chalubbiskiego 5, PL-02004 Warsaw, Poland

[4] Inst Psychiat & Neurol, Dept Neurol 2, Sobieskiego 9, PL-02957 Warsaw, Poland

[5] Med Univ Warsaw, Ctr Preclin Res & Technol CePT, Dept Expt & Clin Pharmacol, Banacha 1B, PL-02097 Warsaw, Poland

[6] Maria Sklodowska Curie Natl Res Inst Oncol, Dept Neurosurg, WK Roentgena 5, PL-02781 Warsaw, Poland

来源：

CYTOKINE | 2022年 / 151卷

关键词：

Progranulin; Breast cancer; Biomarker; Metastasis; Cancer drug resistance; GRANULIN-EPITHELIN PRECURSOR; GROWTH-FACTOR; GP88; PROGRANULIN; MESENCHYMAL TRANSITION; TAMOXIFEN RESISTANCE; C-MYC; EXPRESSION; PROMOTES; CELLS; PROLIFERATION;

D O I：

10.1016/j.cyto.2022.155803

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Breast cancer constitute a common type of oncological disease with a highlighted mortality rate. In recent years, researchers have introduced progranulin (PGRN) as an novel potential biomarker and associated its function with higher risk factor for development of breast cancer. The present review article collects evidence on the association of PGRN with clinicopathological features and drug resistance in the patients with breast cancer. The results of this study suggested the use of routine determination of PGRN in the clinic as a reliable biomarker for screening people at high risk or as early indication of breast cancer. Targeting PGRN and its associated signaling pathways and receptors, such as sortilin (SORT1), could also cover a novel therapeutic strategy in the breast cancer.

引用

页数：9

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