A novel near-infrared fluorescent probe based on triphenylamine derivatives for the rapid and sensitive detection of heparin

被引：14

作者：

Liu, Mingming ^{[1
]}

Cao, Jian ^{[1
]}

Huang, Cuiping ^{[1
]}

Zhang, Meijuan ^{[1
]}

Li, Yanan ^{[1
]}

Wang, Chuanxiao ^{[1
]}

机构：

[1] Shanghai Univ Engn Sci, Sch Chem & Chem Engn, 333 Longteng Rd, Shanghai 201600, Peoples R China

来源：

ANALYST | 2022年 / 147卷 / 15期

关键词：

AGGREGATION-INDUCED EMISSION; PROTAMINE; TIME;

D O I：

10.1039/d2an00254j

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In this study, a positively charged near-infrared fluorescent probe (TPA-P+) was constructed by connecting a pyridine cation with triphenylamine and successfully used for the detection of heparin. The probe has the following characteristics: (1) TPA-P+ exhibited both AIE and TICT characteristics. (2) TPA-P+ could detect heparin by the introduction of a pyridine cation into TPA-P+, which increased the electrostatic interaction between the probe and heparin. (3) The probe has high sensitivity and good selectivity towards heparin and responds quickly. (4) Heparin detection using TPA-P+ was verified by protamine and was found to be reversible and effective. (5) The fluorescence intensity of TPA-P+ has good linearity with heparin concentration in the range of 0-16.0 mu g mL(-1) in human serum albumin.

引用

页码：3504 / 3513

页数：10

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