Angiotensin-converting enzyme gene variant and its levels: risk factors for myocardial infarction in a South Indian population

被引：0
作者：
Reddy, Pulla B. [1 ,2 ]
Babu, Srikanth B. M., V [1 ,2 ]
Karunakar, Venkata K. [1 ,2 ]
Yasovanthi, J. [1 ,2 ]
Munshi, A. [1 ,2 ]
Kumar, Sampath P. [3 ]
Sharath, A. [3 ]
Jyothy, A. [1 ,2 ]
机构：
[1] Osmania Univ, Inst Genet, Hyderabad 500016, Andhra Pradesh, India
[2] Osmania Univ, Hosp Genet Dis, Hyderabad 500016, Andhra Pradesh, India
[3] Osmania Gen Hosp, Dept Cardiol, Hyderabad 500012, Andhra Pradesh, India
来源：
SINGAPORE MEDICAL JOURNAL | 2010年 / 51卷 / 07期
关键词：
ACE activity; angiotensin-converting enzyme; first-degree relatives; I/D gene polymorphism; myocardial infarction; South Indian population; CORONARY-ARTERY-DISEASE; INSERTION/DELETION POLYMORPHISM; DELETION POLYMORPHISM; ACE; ASSOCIATION; STROKE; SYSTEM;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Introduction: Recently, there has been increasing evidence that genetic variation in the angiotensin-converting enzyme (ACE) plays an important role in myocardial infarction. Therefore, the present study was carried out with the aim of investigating the association of the ACE gene insertion/deletion (I/D) polymorphism and its levels in myocardial infarction patients and their first-degree relatives (FDRs). Methods : 206 patients with myocardial infarction, 168 FDRs and 210 control subjects were enrolled in the study. ACE I/D polymorphism was determined using the polymerase chain reaction method. Serum ACE levels were measured using the photometric method. Results: The DD genotype and ACE activity were significantly higher in patients (p-value is 0.00006 and 0.0001, respectively) and FDRs (p-value is 0.003 and 0.04, respectively) compared with the controls. Conclusion: ACE DD genotype and ACE levels are important risk factors for myocardial infarction. This study indicates that the higher frequency of the DD genotype and ACE levels observed in FDRs may increase susceptibility to developing myocardial infarction.
引用
收藏
页码：576 / 581
页数：6
相关论文
共 50 条
[41]   A meta-analysis of the association of the deletion allele of the angiotensin-converting enzyme gene with myocardial infarction [J].
Samani, NJ ;
Thompson, JR ;
OToole, L ;
Channer, K ;
Woods, KL .
CIRCULATION, 1996, 94 (04) :708-712
[42]   ANGIOTENSIN-CONVERTING ENZYME GENE POLYMORPHISM IS ASSOCIATED WITH MYOCARDIAL-INFARCTION BUT NOT WITH DEVELOPMENT OF CORONARY STENOSIS [J].
LUDWIG, E ;
CORNELI, PS ;
ANDERSON, JL ;
MARSHALL, HW ;
LALOUEL, JM ;
WARD, RH .
CIRCULATION, 1995, 91 (08) :2120-2124
[43]   ANGIOTENSIN-CONVERTING ENZYME GENE DELETION ALLELE IS INDEPENDENTLY AND STRONGLY ASSOCIATED WITH CORONARY ATHEROSCLEROSIS AND MYOCARDIAL-INFARCTION [J].
ARBUSTINI, E ;
GRASSO, M ;
FASANI, R ;
KLERSY, C ;
DIEGOLI, M ;
PORCU, E ;
BANCHIERI, N ;
FORTINA, P ;
DANESINO, C ;
SPECCHIA, G .
BRITISH HEART JOURNAL, 1995, 74 (06) :584-591
[44]   Effect of angiotensin converting enzyme gene I/D polymorphism in South Indian children with nephrotic syndrome [J].
Ramanathan, Aravind Selvin Kumar ;
Karuppiah, Balakrishnan ;
Vijayan, Murali ;
Raju, Kamaraj ;
Mani, Dhivakar ;
Chinniah, Rathika ;
Thirunavukkarasu, Manikandan ;
Ravi, Padma Malini ;
Krishnan, Jeyaram Illiayaraja ;
Senguttuvan, Prabha .
JOURNAL OF BIOMEDICAL RESEARCH, 2019, 33 (03) :201-207
[45]   Angiotensin-converting enzyme gene polymorphism and risk of insulin resistance in PCOS [J].
Celik, Onder ;
Yesilada, Elif ;
Hascalik, Seyma ;
Celik, Nilufer ;
Sahin, Ibrahim ;
Keskin, Lezzan ;
Ozerol, Elif .
REPRODUCTIVE BIOMEDICINE ONLINE, 2010, 20 (04) :492-498
[46]   Angiotensin-converting enzyme gene polymorphisms and nonarteritic anterior ischemic optic neuropathy risk [J].
Xu, Peng ;
Ma, Lin ;
Shao, Lin .
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2016, 9 (08) :8657-8662
[47]   Effects of angiotensin-converting enzyme inhibition on angiotensin and bradykinin peptides in rats with myocardial infarction [J].
Duncan, AM ;
Burrell, LM ;
Kladis, A ;
Campbell, DJ .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1996, 28 (06) :746-754
[48]   Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with increased plasma angiotensin-converting enzyme activity but not with increased risk for myocardial infarction and coronary artery disease [J].
Winkelmann, BR ;
Nauck, M ;
Klein, B ;
Russ, AP ;
Bohm, BO ;
Siekmeier, R ;
Ihnken, K ;
Verho, M ;
Gross, W ;
Marz, W .
ANNALS OF INTERNAL MEDICINE, 1996, 125 (01) :19-+
[49]   Association of angiotensin converting enzyme gene insertion/deletion polymorphism with essential hypertension in south Indian population [J].
Krishnan, Ramalingam ;
Sekar, Durairaj ;
Karunanithy, Santha ;
Subramanium, Sethupathy .
GENES & DISEASES, 2016, 3 (02) :159-163
[50]   Lack of Association between Angiotensin Converting Enzyme (ACE) Insertion/Deletion Polymorphism (rs4340) and Risk of Myocardial Infarction [J].
Ibrahim, Safaa Awad Mohammed ;
Ali, Elshazali Widaa .
MEDICAL SCIENCE, 2020, 24 (106) :3987-3993
12345