Hereditary Colorectal Cancer Syndromes and Genetic Testing

被引：11

作者：

Macaron, Carole ^{[1
]}

Leach, Brandie H. ^{[2
]}

Burke, Carol A. ^{[1
]}

机构：

[1] Cleveland Clin, Dept Gastroenterol & Hepatol, Cleveland, OH 44195 USA

[2] Cleveland Clin, Genom Med Inst, Cleveland, OH 44195 USA

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2015年 / 111卷 / 01期

关键词：

colon cancer; hereditary syndromes; genetic testing; FAMILIAL ADENOMATOUS POLYPOSIS; PEUTZ-JEGHERS-SYNDROME; LARGE GENOMIC DELETIONS; JUVENILE POLYPOSIS; LYNCH-SYNDROME; ILEORECTAL ANASTOMOSIS; CYCLOOXYGENASE-2; INHIBITOR; GERMLINE MUTATIONS; RISK; MUTYH;

D O I：

10.1002/jso.23706

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC) is a leading cause of cancer and cancer deaths in the Western world. Approximately 5-10% of CRC are hereditary, due to a defined genetic cause. Individuals and families affected with a hereditary CRC syndrome exhibit benign and malignant extra-intestinal tumors, require aggressive cancer screening and benefit from management by a multi-disciplinary team of professionals. The clinical manifestations, genetic causes and current management of patients with hereditary colon cancer syndrome is provided. J. Surg. Oncol. 2015 111:103-111. (c) 2014 Wiley Periodicals, Inc.

引用

页码：103 / 111

页数：9

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