In Vitro and In Vivo Activities of E-101 Solution against Acinetobacter baumannii Isolates from US Military Personnel

被引：3
作者：
Denys, G. A. [1 ]
Davis, J. C. [2 ]
O'Hanley, P. D. [3 ]
Stephens, J. T., Jr. [3 ]
机构：
[1] Indiana Univ, Hlth Pathol Lab, Indianapolis, IN 46202 USA
[2] Ric Biosci LLC, Concord, OH 44077 USA
[3] Exoxemis Inc, Little Rock, AR 72201 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 07期
关键词：
MYELOPEROXIDASE; BACTERIA; BINDING; OXIDANT; OXYGEN;
D O I：
10.1128/AAC.01606-10
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We evaluated the in vitro and in vivo activity of a novel topical myeloperoxidase-mediated antimicrobial, E-101 solution, against 5 multidrug-resistant Acinetobacter baumannii isolates recovered from wounded American soldiers. Time-kill studies demonstrated rapid bactericidal activity against all A. baumannii strains tested in the presence of 3% blood. The in vitro bactericidal activity of E-101 solution against A. baumannii strains was confirmed in a full-thickness excision rat model. Additional in vivo studies appear warranted.
引用
收藏
页码：3603 / 3608
页数：6
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