Primary pleomorphic leiomyosarcoma of descending mesocolon

Mesenteric tumors range from benign cysts to aggressive malignancies and pose both diagnostic and therapeutic challenge. Leiomyosarcomas are rare tumors of the digestive tract comprising <0.1% of colorectal tumors. Similarities between mesenchymal tumors of the digestive tract make histological diagnosis difficult. We report a case of 53-year-old female diagnosed with leiomyosarcoma of descending mesocolon, who has undergone surgery following neoadjuvant chemotherapy and has been on regular follow-up for 2 years. This case signifies the diagnostic difficulties encountered in these rare tumors with a review of the literature.