Highly Enantioselective Transfer Hydrogenation of Ketones with Chiral (NH)2P2 Macrocyclic Iron(II) Complexes

被引：129

作者：

Bigler, Raphael ^{[1
]}

Huber, Raffael ^{[1
]}

Mezzetti, Antonio ^{[1
]}

机构：

[1] Eidgenoss Tech Hsch ETH Zurich, Dept Chem & Angew Biowissensch, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 17期

基金：

瑞士国家科学基金会;

关键词：

alcohols; asymmetric catalysis; hydrogen transfer; iron; macrocyclic ligands; ASYMMETRIC TRANSFER HYDROGENATION; N-N-P; AROMATIC KETONES; TRANSITION-METAL; PNNP LIGAND; CATALYSIS; ACETOPHENONE; REDUCTION; IMINES; AMINES;

D O I：

10.1002/anie.201501807

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bis(isonitrile) iron(II) complexes bearing a C-2-symmetric diamino (NH)(2)P-2 macrocyclic ligand efficiently catalyze the hydrogenation of polar bonds of a broad scope of substrates (ketones, enones, and imines) in high yield (up to 99.5%), excellent enantioselectivity (up to 99% ee), and with low catalyst loading (generally 0.1 mol%). The catalyst can be easily tuned by modifying the substituents of the isonitrile ligand.

引用

页码：5171 / 5174

页数：4

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