Chiral Pyrrolidines and Piperidines from Enantioselective Rhodium-Catalyzed Cascade Arylative Cyclization

被引：39

作者：

Serpier, Fabien ^{[1
]}

Flamme, Benjamin ^{[1
]}

Brayer, Jean-Louis ^{[2
]}

Folleas, Benoit ^{[2
]}

Darses, Sylvain ^{[1
]}

机构：

[1] PSL Res Univ, Chim ParisTech CNRS, Inst Rech Chim Paris, F-75005 Paris, France

[2] ZAC Moulin, Diverchim, F-95700 Roissy En France, France

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 07期

关键词：

ARYLBORONIC ACIDS; ASYMMETRIC 1,4-ADDITION; DIENE LIGANDS; TANDEM; EFFICIENT; CARBOPALLADATION; TRANSFORMATIONS; CONSTRUCTION; COMPLEXES; ALDEHYDES;

D O I：

10.1021/acs.orglett.5b00493

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new rhodium-catalyzed asymmetric arylative cyclization of nitrogen-tethered alkyne-enoate with arylboronic acids is described. In this process two new carbon-carbon bonds and one stereocenter are formed, providing access to pyrrolidines and piperidines with good enantioselectivities by to the use of C-1-symmetric chiral monosubstituted diene ligands.

引用

页码：1720 / 1723

页数：4

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