Infection Risk With Biologic Therapy in Patients With Inflammatory Bowel Disease

被引：29
作者：
Hindryckx, Pieter [1 ]
Novak, Gregor [2 ]
Bonovas, Stefanos [3 ]
Peyrin-Biroulet, Laurent [4 ]
Danese, Silvio [3 ,5 ]
机构：
[1] Univ Ghent, Dept Gastroenterol, Ghent, Belgium
[2] Univ Ljubljana, Dept Gastroenterol, Med Ctr, Ljubljana, Slovenia
[3] Humanitas Clin & Res Ctr, IBD Ctr, Dept Gastroenterol, Milan, Italy
[4] Lorraine Univ, Univ Hosp Nancy, Inserm, U954, Vandoeuvre Les Nancy, France
[5] Humanitas Univ, Dept Biomed Sci, Milan, Italy
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2017年 / 102卷 / 04期
关键词：
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; EVENT TRIAL TARGET; CARDIOVASCULAR SAFETY; CENTRAL SENSITIZATION; CHRONIC PAIN; CYCLOOXYGENASE ISOFORMS; OSTEOARTHRITIS PAIN; ARTHRITIS RESEARCH; KNEE REPLACEMENT; COX-2; INHIBITION;
D O I：
10.1002/cpt.791
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The development of biologic drugs revolutionized the management of inflammatory bowel diseases: Crohn's disease and ulcerative colitis. However, while their efficacy has been well established, it remains uncertain to what extent biologic treatments may be associated with important safety risks, such as serious infections, opportunistic infections, or tuberculosis reactivation. Herein, we review and discuss the current evidence on the infection risk associated with biologic therapy in patients with inflammatory bowel disease (IBD).
引用
收藏
页码：633 / 641
页数：9
相关论文
共 101 条
  • [1] CLINICAL TRIAL OF ADJUNCTIVE CELECOXIB TREATMENT IN PATIENTS WITH MAJOR DEPRESSION: A DOUBLE BLIND AND PLACEBO CONTROLLED TRIAL
    Akhondzadeh, Shahin
    Jafari, Sara
    Raisi, Firoozeh
    Nasehi, Abbas Ali
    Ghoreishi, Aboulfazl
    Salehi, Bahman
    Mohebbi-Rasa, Soodeh
    Raznahan, Maedeh
    Kamalipour, Abbas
    [J]. DEPRESSION AND ANXIETY, 2009, 26 (07) : 607 - 611
  • [2] Predictive factors and clinical biomarkers for treatment in patients with chronic pain caused by osteoarthritis with a central sensitisation component
    Akinci, A.
    Al Shaker, M.
    Chang, M. H.
    Cheung, C. W.
    Danilov, A.
    Jose Duenas, H.
    Kim, Y. C.
    Guillen, R.
    Tassanawipas, W.
    Treuer, T.
    Wang, Y.
    [J]. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2016, 70 (01) : 31 - 44
  • [3] COX-2-derived endocannabinoid metabolites as novel inflammatory mediators
    Alhouayek, Mireille
    Muccioli, Giulio G.
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2014, 35 (06) : 284 - 292
  • [4] Afferent pain pathways: a neuroanatomical review
    Almeida, TF
    Roizenblatt, S
    Tufik, S
    [J]. BRAIN RESEARCH, 2004, 1000 (1-2) : 40 - 56
  • [5] Periganglionic inflammation elicits a distally radiating pain hypersensitivity by promoting COX-2 induction in the dorsal root ganglion
    Amaya, Fumimasa
    Samad, Tarek A.
    Barrett, Lee
    Broom, Daniel C.
    Woolf, Clifford J.
    [J]. PAIN, 2009, 142 (1-2) : 59 - 67
  • [6] Angst F, 2001, ARTHRIT RHEUM-ARTHR, V45, P384, DOI 10.1002/1529-0131(200108)45:4<384::AID-ART352>3.0.CO
  • [7] 2-0
  • [8] [Anonymous], 2011, REL PAIN AM BLUEPR T
  • [9] [Anonymous], 2017, N ENGL J MED
  • [10] [Anonymous], EUR ARCH PSYCHIAT CL
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