Novel potentiometric sensors for determination of ondansetron hydrochloride in pure and dosage form

A new and sensitive potentiometric method has been developed and characterized for four novel sensors responsive to ondansetron hydrochloride. The potentiometric sensor method includes advancement of ondansetron hydrochloride sensors using a membrane comprised of molybdophosphoric acid (MPA) and ondansetron as an electro-active material in a polyvinylchloride (PVC) matrix membrane plasticized with di-butyl phthalate (DBPH), ortho-nitrophenyloctyl ether (O-NPOE), di-octyl phthalate (DOPH), or di-butyl phosphate (DBP). The validity of sensors in the present work has been examined, and steady and reproducible responses were obtained over the concentration ranges of 7.3 x 10(-5) to 1.0 x 10(-2), 6.6 x 10(-6) to 1.0 x 10(-2), 1.0 x 10(-5) to 1.0 x 10(-2), and 2.0 x 10(-5) to 1.0 x 10(-2) M for DBPH-, O-NPOE-, DOPH-, and DBP-ondansetron, respectively. The sensors revealed Nernstian gradients of 59.61 +/- 0.50, 57.71 +/- 0.23, 53.01 +/- 0.14, and 53.20 +/- 0.35 mV per decade individually with pH ranges of 2.5-5.5 in DBPH and 3.5-5.0 in O-NPOE electrodes, and 4.0-5.5 for both individual DOPH and DBP plasticized film-based sensors. The time responses for the sensors were 30, 32, 31, and 29 s for DBPH-, O-NPOE-, DOPH-, and DBP-ondansetron, respectively. The developed sensors also exhibited high selectivity towards ondansetron hydrochloride against different interfering species of inorganic particles with long-term stability of approximately 41, 36, 18, and multiple days for the DBPH, O-NPOE, DOPH, and DBP electrodes.