Sex differences in age-related changes in the sleep-wake cycle

被引:80
作者
Carrier, Julie [1 ,2 ,3 ]
Semba, Kazue [4 ,5 ,6 ]
Deurveilher, Samuel [4 ]
Drogos, Lauren [7 ,8 ]
Cyr-Cronier, Jessica [1 ]
Lord, Catherine [1 ]
Sekerovick, Zoran [1 ]
机构
[1] Hop Sacre Coeur Montreal, Ctr Adv Res Sleep Med, Montreal, PQ, Canada
[2] Univ Montreal, Inst Univ Geriatrie Montreal, Montreal, PQ, Canada
[3] Univ Montreal, Dept Psychol, Montreal, PQ, Canada
[4] Dalhousie Univ, Dept Med Neurosci, Halifax, NS, Canada
[5] Dalhousie Univ, Dept Psychiat, Halifax, NS, Canada
[6] Dalhousie Univ, Dept Psychol & Neurosci, Halifax, NS, Canada
[7] Univ Calgary, Dept Physiol & Pharmacol, Calgary, AB, Canada
[8] Univ Calgary, Dept Clin Neurosci, Calgary, AB, Canada
基金
加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词
Sleep; Aging; Sex differences; Circadian rhythms; Testosterone; Estrogens; Menopause; Andropause; EYE-MOVEMENT SLEEP; UNFOLDED PROTEIN RESPONSE; SLOW-WAVE SLEEP; OVARIECTOMIZED FEMALE RATS; CIRCADIAN TIMING SYSTEM; MENOPAUSAL HOT FLASHES; YOUNG HEALTHY-MEN; MENSTRUAL-CYCLE; GENDER-DIFFERENCES; MIDLIFE WOMEN;
D O I
10.1016/j.yfrne.2017.07.004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Age-related changes in sleep and circadian regulation occur as early as the middle years of life. Research also suggests that sleep and circadian rhythms are regulated differently between women and men. However, does sleep and circadian rhythms regulation age similarly in men and women? In this review, we present the mechanisms underlying age-related differences in sleep and the current state of knowledge on how they interact with sex. We also address how testosterone, estrogens, and progesterone fluctuations across adulthood interact with sleep and circadian regulation. Finally, we will propose research avenues to unravel the mechanisms underlying sex differences in age-related effects on sleep.
引用
收藏
页码:66 / 85
页数:20
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