Effect of 1α-hydroxyvitamin D3 and egg-shell calcium on bone metabolism in ovariectomized osteoporotic model rats

被引:19
作者
Hirasawa, T [1 ]
Omi, N [1 ]
Ezawa, I [1 ]
机构
[1] Japan Womens Univ, Sch Home Econ, Dept Food & Nutr, Bunkyo Ku, Tokyo 1128681, Japan
关键词
egg-shell Ca; 1 alpha(OH)D-3; bone mineral density; serum Ca level; intestinal Ca absorption;
D O I
10.1007/s007740170045
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Egg-shell calcium (Ca) is one of the effective Ca sources for bone metabolism. In the present study, we investigated whether egg-shell Ca had similar effects compared with calcium carbonate (CaCO3) when vitamin D-3 (1 alpha (OH)D-3) treatment was given to an osteoporotic rat model. In both 1 alpha (OH)D-3-supplemented and -unsupplemented rats, the bone mineral density (BMD) of the lumber spine in the vitamin-supplemented group increased significantly compared with the unsupplemented group. In a Ca balance study, there were also significant differences in intestinal Ca absorption, urinary Ca and fecal Ca between the vitamin-supplemented and -unsupplemented groups. These results show that egg-shell Ca could have similar effects to CaCO3 on bone metabolism. In contrast with CaCO3, vitamin D-3 supplementation did not significantly increase serum Ca levels in the egg-shell Ca group; however, the mechanism of Ca absorption is still unclear. Our results suggest that egg-shell Ca may be an effective nutrient in Ca metabolism for people treated with vitamin D-3.
引用
收藏
页码:84 / 88
页数:5
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