Tyrosine kinase inhibitors and signal transduction modulators: Rationale and current status as chemopreventive agents for prostate cancer

被引:16
作者
Bergan, RC
Waggle, DH
Carter, SK
Horak, I
Slichenmyer, W
Meyers, M
机构
[1] Aventis Inc, Parsippany, NJ USA
[2] Parke Davis & Co, Ann Arbor, MI USA
[3] Pharmacia, Peapack, NJ USA
[4] Sugen Inc, San Francisco, CA USA
[5] Prot Technol Inc, St Louis, MO USA
[6] Northwestern Univ, Robert H Lurie Canc Ctr, Chicago, IL 60611 USA
[7] Northwestern Univ, Sch Med, Dept Med, Div Hematol Oncol, Chicago, IL 60611 USA
关键词
D O I
10.1016/S0090-4295(00)00946-8
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
intimately associated with carcinogenesis and regulated by Cell growth and differentiation are processes tyrosine kinases and other signaling proteins. Identification of drugs that target signaling molecules is hampered by both the large number of targets and the complex nature of signaling cascades. Optimal development of chemopreventive agents must take into account affinity for the target, pharmacology, and safety profile of the agent, Validated biomarkers will allow the optimal implementation of chemopreventive trials. Directed epidemiologic studies can lead to the identification of lead compounds for chemoprevention, such as genistein. Therefore, agents targeted to pathways and molecules of known biological importance in the prostate hold the promise of clinical efficacy against prostate cancer in a chemopreventive setting. (C) 2001, Elsevier Science Inc.
引用
收藏
页码:77 / 80
页数:4
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