ISG15 secretion exacerbates inflammation in SARS-CoV-2 infection

被引：35

作者：

Cao, Xuetao ^{[1
,2
]}

机构：

[1] Nankai Univ, Coll Life Sci, Tianjin, Peoples R China

[2] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Immunol, Beijing, Peoples R China

来源：

NATURE IMMUNOLOGY | 2021年 / 22卷 / 11期

关键词：

D O I：

10.1038/s41590-021-01056-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Conjugation of the ubiquitin-like protein ISG15 to targets (ISGylation) benefits antiviral defense. However, SARS-CoV-2 induces human macrophages to preferentially secrete ISG15 via its papain-like protease, and extracellular non-conjugated ISG15 acts as a cytokine to exacerbate SARS-CoV-2-triggered inflammation.

引用

页码：1360 / 1362

页数：3

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