Enantioselective dehydrohalogenation using chiral alkoxides: Design of a catalytic system allowing access to axially dissymmetric compounds

被引：14

作者：

Amadji, M ^{[1
]}

Vadecard, J ^{[1
]}

Cahard, D ^{[1
]}

Duhamel, L ^{[1
]}

Duhamel, P ^{[1
]}

Plaquevent, JC ^{[1
]}

机构：

[1] Univ Rouen, Fac Sci, IRCOF, UPRES A CNRS 6014,Lab Fonct Azotees & Oxygenees C, F-76821 Mont St Aignan, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 16期

关键词：

D O I：

10.1021/jo9806456

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of chiral alkoxides obtained from ephedrines for enantioselective proton abstraction is described in full. These reagents allow the practical obtention of axially dissymmetric 1,3-dioxanes via highly enantioselective dehydrohalogenation reactions. The conditions for a catalytic use of these chiral alkoxides are defined.

引用

页码：5541 / 5546

页数：6

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