Design of the Swiss Atrial Fibrillation Cohort Study (Swiss-AF): structural brain damage and cognitive decline among patients with atrial fibrillation

被引：61

作者：

David, Conen ^{[1
,2
,3
]}

Nicolas, Rodondi ^{[4
,5
]}

Andreas, Mueller ^{[6
]}

Juerg, Beer H. ^{[7
]}

Angeloh, Auricchio ^{[8
]}

Peter, Ammann ^{[9
]}

Daniel, Hayoz ^{[10
]}

Richard, Kobza ^{[11
]}

Giorgio, Moschovitis ^{[12
]}

Dipen, Shah ^{[13
]}

Juerg, Schlaepfer ^{[14
]}

Jan, Novak ^{[15
]}

Marcello, Di Valentino ^{[16
]}

Paul, Erne ^{[17
]}

Christian, Sticherling ^{[1
,2
]}

Leo, Bonati H. ^{[18
,19
]}

Georg, Ehret ^{[13
]}

Laurent, Roten ^{[20
,21
]}

Urs, Fischer ^{[21
,22
]}

Andreas, Monsch ^{[23
]}

Christoph, Stippich ^{[24
]}

Jens, Wuerfel ^{[25
]}

Matthias, Schwenkglenks ^{[26
]}

Michael, Kuehne ^{[1
,2
]}

Stefan, Osswald ^{[1
,2
]}

机构：

[1] Univ Basel Hosp, Dept Med, Div Cardiol, Basel, Switzerland

[2] Cardiovascular Res Inst Basel, Basel, Switzerland

[3] McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada

[4] Univ Bern, Inst Primary Hlth Care BIHAM, Bern, Switzerland

[5] Univ Bern, Univ Hosp Bern, Dept Gen Internal Med, Inselspital, Bern, Switzerland

[6] Triemli Hosp Zurich, Dept Cardiol, Zurich, Switzerland

[7] Univ Hosp Zurich, Cantonal Hosp Baden & Mol Cardiol, Dept Med, Zurich, Switzerland

[8] Cardioctr Ticino Lugano, Dept Cardiol, Lugano, Switzerland

[9] Kantonsspital St Gallen, Dept Cardiol, St Gallen, Switzerland

[10] HFR Hop Cantonal Fribourg, Dept Internal Med, Fribourg, Switzerland

[11] Luzerner Kantonsspital, Dept Cardiol, Luzern, Switzerland

[12] Osped Regionale Lugano, Dept Cardiol, Lugano, Switzerland

[13] Univ Hosp Geneva, Dept Med Special, Serv Cardiol, Geneva, Switzerland

[14] CHU Vaudois, Dept Cardiol, Lausanne, Switzerland

[15] Burgerspital, Dept Cardiol, Solothurn, Switzerland

[16] Osped San Giovanni Bellinzona, Dept Cardiol, Bellinzona, Switzerland

[17] Univ Hosp Basel, Dept Biomed, Basel, Switzerland

[18] Univ Hosp Basel, Dept Clin Res, Stroke Ctr, Basel, Switzerland

[19] Univ Hosp Basel, Dept Clin Res, Neurol Div, Basel, Switzerland

[20] Bern Univ Hosp, Inselspital, Dept Cardiol, Bern, Switzerland

[21] Univ Bern, Bern, Switzerland

[22] Univ Hosp Bern, Inselspital, Dept Radiol, Bern, Switzerland

[23] Univ Basel, Felix Platter Hosp Basel, Univ Altersmed, Memory Clin, Basel, Switzerland

[24] Univ Hosp Basel, Div Diagnost & Intervent Neuroradiol, Basel, Switzerland

[25] Med Image Anal Ctr MIAC AG, Basel, Switzerland

[26] Univ Zurich, Epidemiol Biostat & Prevent Inst, Zurich, Switzerland

来源：

SWISS MEDICAL WEEKLY | 2017年 / 147卷

基金：

瑞士国家科学基金会;

关键词：

atrial fibrillation; cognitive decline; dementia; magnetic resonance imaging; stroke: epidemiology;

D O I：

10.4414/smw.2017.14467

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND: Several studies found that patients with atrial fibrillation (AF) have an increased risk of cognitive decline and dementia over time. However, the magnitude of the problem, associated risk factors and underlying mechanisms remain unclear. METHODS: This article describes the design and methodology of the Swiss Atrial Fibrillation (Swiss-AF) Cohort Study, a prospective multicentre national cohort study of 2400 patients across 13 sites in Switzerland. Eligible patients must have documented AF. Main exclusion criteria are the inability to provide informed consent and the presence of exclusively short episodes of reversible forms of AF. All patients undergo extensive phenotyping and genotyping, including repeated assessment of cognitive functions, quality of life, disability, electrocardiography and cerebral magnetic resonance imaging. We also collect in-formation on health related costs, and we assemble a large biobank. Key clinical outcomes in Swiss-AF are death, stroke, systemic embolism, bleeding, hospitalisation for heart failure and myocardial infarction. Information on outcomes and updates on other characteristics are being collected during yearly follow-up visits. RESULTS: Up to 7 April 2017, we have enrolled 2133 patients into Swiss-AF. With the current recruitment rate of 15 to 20 patients per week, we expect that the target sample size of 2400 patients will be reached by summer 2017. CONCLUSION: Swiss-AF is a large national prospective cohort of patients with AF in Switzerland. This study will provide important new information on structural and functional brain damage in patients with AF and on other AF related complications, using a large variety of genetic, phenotypic and health economic parameters.

引用

页数：9

共 34 条

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