Imaging the Pathophysiology of Essential Tremor-A Systematic Review

被引:40
作者
Holtbernd, Florian [1 ,2 ,3 ]
Shah, N. Jon [1 ,2 ,3 ]
机构
[1] Forschungszentrum Julich, Inst Neurosci & Med INM INM 4 11, Julich, Germany
[2] Rhein Westfael TH Aachen Univ, Forschungszentrum Julich, JARA BRAIN Inst Mol Neurosci & Neuroimaging, Aachen, Germany
[3] Rhein Westfael TH Aachen Univ, Dept Neurol, Aachen, Germany
来源
FRONTIERS IN NEUROLOGY | 2021年 / 12卷
关键词
essential tremor; pathophysiology; magnetic resonance imaging (MRI); tremor network; PET; SPECT; gamma-aminobutyric acid; VOXEL-BASED MORPHOMETRY; CEREBELLAR GRAY-MATTER; POSITRON-EMISSION-TOMOGRAPHY; REFLEX RECOVERY CYCLE; PARKINSONS-DISEASE; GLUCOSE-METABOLISM; DENTATE NUCLEUS; MOVEMENT-DISORDERS; IRON DEPOSITION; RESTING TREMOR;
D O I
10.3389/fneur.2021.680254
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: The pathophysiology underlying essential tremor (ET) still is poorly understood. Recent research suggests a pivotal role of the cerebellum in tremor genesis, and an ongoing controversy remains as to whether ET constitutes a neurodegenerative disorder. In addition, mounting evidence indicates that alterations in the gamma-aminobutyric acid neurotransmitter system are involved in ET pathophysiology. Here, we systematically review structural, functional, and metabolic neuroimaging studies and discuss current concepts of ET pathophysiology from an imaging perspective. Methods: We conducted a PubMed and Scopus search from 1966 up to December 2020, entering essential tremor in combination with any of the following search terms and their corresponding abbreviations: positron emission tomography (PET), single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), and gamma-aminobutyric acid (GABA). Results: Altered functional connectivity in the cerebellum and cerebello-thalamico-cortical circuitry is a prevalent finding in functional imaging studies. Reports from structural imaging studies are less consistent, and there is no clear evidence for cerebellar neurodegeneration. However, diffusion tensor imaging robustly points toward microstructural cerebellar changes. Radiotracer imaging suggests that the dopaminergic axis is largely preserved in ET. Similarly, measurements of nigral iron content and neuromelanin are unremarkable in most studies; this is in contrast to Parkinson's disease (PD). PET and MRS studies provide limited evidence for cerebellar and thalamic GABAergic dysfunction. Conclusions: There is robust evidence indicating that the cerebellum plays a key role within a multiple oscillator tremor network which underlies tremor genesis. However, whether cerebellar dysfunction relies on a neurodegenerative process remains unclear. Dopaminergic and iron imaging do not suggest a substantial overlap of ET with PD pathophysiology. There is limited evidence for alterations of the GABAergic neurotransmitter system in ET. The clinical, demographical, and genetic heterogeneity of ET translates into neuroimaging and likely explains the various inconsistencies reported.
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页数:17
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