MnCl2-Catalyzed C-H Alkylations with Alkyl Halides

被引：52

作者：

Liu, Weiping ^{[1
]}

Cera, Gianpiero ^{[1
]}

Oliveira, Joao C. A. ^{[1
]}

Shen, Zhigao ^{[1
]}

Ackermann, Lutz ^{[1
]}

机构：

[1] Georg August Univ, Inst Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2017年 / 23卷 / 48期

基金：

欧洲研究理事会;

关键词：

alkylation; C-H activation; manganese; mechanism; selectivity; PALLADIUM-CATALYZED ARYLATION; BOND FUNCTIONALIZATIONS; CARBON-HYDROGEN; ACTIVATION; METHYLATION; ARYL; CARBOXAMIDES; STRATEGY; ESTERS; IMINES;

D O I：

10.1002/chem.201703191

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

C-H alkylations with challenging beta-hydrogen-containing alkyl halides were accomplished with sustainable MnCl2 as the catalyst under phosphine-ligand-free conditions. The proximity-induced benzamide C-H activation occurred with ample substrate scope through rate-determining C-H metalation, also setting the stage for manganese-catalyzed oxidative C-H methylations.

引用

页码：11524 / 11528

页数：5

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