Synchrotron crystallography

被引：100

作者：

Hendrickson, WA ^{[1
]}

机构：

[1] Columbia Univ, Howard Hughes Med Inst, Dept Biochem & Mol Biophys, New York, NY 10032 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2000年 / 25卷 / 12期

关键词：

D O I：

10.1016/S0968-0004(00)01721-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The past decade has seen an explosive growth in atomic-level structures determined by X-ray crystallography. Synchrotron radiation and a number of technical advances related quite directly to its development have fueled this growth. With the most recent advances coming to be used collectively and new resources being built, the foundation is laid for a dramatic further expansion of synchrotron crystallography in the next decade. Both the high-throughput applications of structural genomics and also the challenging studies of macromolecular machinery are expected to flourish.

引用

页码：637 / 643

页数：7

共 40 条

[1]

ALSNIELSEN J, 2000, ELEMENTS MODERN XRAY

[2] The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution [J].

Ban, N ;

Nissen, P ;

Hansen, J ;

Moore, PB ;

Steitz, TA .

SCIENCE, 2000, 289 (5481) :905-920

[3] Producing selenomethionine-labeled proteins with a baculovirus expression vector system [J].

Bellizzi, JJ ;

Widom, J ;

Kemp, CW ;

Clardy, J .

STRUCTURE, 1999, 7 (11) :R263-R267

[4] X-ray photographs of crystalline pepsin [J].

Bernal, JD ;

Crowfoot, D .

NATURE, 1934, 133 :794-795

[5]

Blundell T. L., 1976, Protein crystallography

[6] Implication of tubby proteins as transcription factors by structure-based functional analysis [J].

Boggon, TJ ;

Shan, WS ;

Santagata, S ;

Myers, SC ;

Shapiro, L .

SCIENCE, 1999, 286 (5447) :2119-2125

[7] Architecture of RNA polymerase II and implications for the transcription mechanism [J].

Cramer, P ;

Bushnell, DA ;

Fu, JH ;

Gnatt, AL ;

Maier-Davis, B ;

Thompson, NE ;

Burgess, RR ;

Edwards, AM ;

David, PR ;

Kornberg, RD .

SCIENCE, 2000, 288 (5466) :640-649

[8] The benefits of atomic resolution [J].

Dauter, Z ;

Lamzin, VS ;

Wilson, KS .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1997, 7 (05) :681-688

[9] Selenium-based MAD phasing: setting the sites on larger structures [J].

Deacon, AM ;

Ealick, SE .

STRUCTURE WITH FOLDING & DESIGN, 1999, 7 (07) :R161-R166

[10] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods [J].

delaFortelle, E ;

Bricogne, G .

MACROMOLECULAR CRYSTALLOGRAPHY, PT A, 1997, 276 :472-494

← 1 2 3 4 →