Synchrotron crystallography

被引:98
作者
Hendrickson, WA [1 ]
机构
[1] Columbia Univ, Howard Hughes Med Inst, Dept Biochem & Mol Biophys, New York, NY 10032 USA
关键词
D O I
10.1016/S0968-0004(00)01721-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The past decade has seen an explosive growth in atomic-level structures determined by X-ray crystallography. Synchrotron radiation and a number of technical advances related quite directly to its development have fueled this growth. With the most recent advances coming to be used collectively and new resources being built, the foundation is laid for a dramatic further expansion of synchrotron crystallography in the next decade. Both the high-throughput applications of structural genomics and also the challenging studies of macromolecular machinery are expected to flourish.
引用
收藏
页码:637 / 643
页数:7
相关论文
共 40 条
  • [1] ALSNIELSEN J, 2000, ELEMENTS MODERN XRAY
  • [2] The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution
    Ban, N
    Nissen, P
    Hansen, J
    Moore, PB
    Steitz, TA
    [J]. SCIENCE, 2000, 289 (5481) : 905 - 920
  • [3] Producing selenomethionine-labeled proteins with a baculovirus expression vector system
    Bellizzi, JJ
    Widom, J
    Kemp, CW
    Clardy, J
    [J]. STRUCTURE, 1999, 7 (11) : R263 - R267
  • [4] X-ray photographs of crystalline pepsin
    Bernal, JD
    Crowfoot, D
    [J]. NATURE, 1934, 133 : 794 - 795
  • [5] Blundell T. L., 1976, Protein crystallography
  • [6] Implication of tubby proteins as transcription factors by structure-based functional analysis
    Boggon, TJ
    Shan, WS
    Santagata, S
    Myers, SC
    Shapiro, L
    [J]. SCIENCE, 1999, 286 (5447) : 2119 - 2125
  • [7] Architecture of RNA polymerase II and implications for the transcription mechanism
    Cramer, P
    Bushnell, DA
    Fu, JH
    Gnatt, AL
    Maier-Davis, B
    Thompson, NE
    Burgess, RR
    Edwards, AM
    David, PR
    Kornberg, RD
    [J]. SCIENCE, 2000, 288 (5466) : 640 - 649
  • [8] The benefits of atomic resolution
    Dauter, Z
    Lamzin, VS
    Wilson, KS
    [J]. CURRENT OPINION IN STRUCTURAL BIOLOGY, 1997, 7 (05) : 681 - 688
  • [9] Selenium-based MAD phasing: setting the sites on larger structures
    Deacon, AM
    Ealick, SE
    [J]. STRUCTURE WITH FOLDING & DESIGN, 1999, 7 (07): : R161 - R166
  • [10] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods
    delaFortelle, E
    Bricogne, G
    [J]. MACROMOLECULAR CRYSTALLOGRAPHY, PT A, 1997, 276 : 472 - 494