Blood dendritic cells in patients with chronic lymphocytic leukaemia

被引：9

作者：

Mami, Naira Ben ^{[1
,2
]}

Mohty, Mohamad ^{[1
,2
,3
,4
]}

Aurran-Schleinitz, Therese ^{[3
]}

Olive, Daniel ^{[1
,2
]}

Gaugler, Beatrice ^{[1
,2
]}

机构：

[1] INSERM, UMR 599, F-13273 Marseille 09, France

[2] Univ Aix Marseille 2, Inst J Paoli I Calmettes, Lab Immunol Tumeurs, F-13273 Marseille 09, France

[3] Inst J Paoli I Calmettes, Dept Hematol, F-13009 Marseille, France

[4] Inst J Paoli I Calmettes, Unite Transplantat & Therapie Cellulaire, F-13009 Marseille, France

来源：

IMMUNOBIOLOGY | 2008年 / 213卷 / 06期

关键词：

chronic lymphocytic leukaemia; dendritic cells; immunotherapy;

D O I：

10.1016/j.imbio.2007.11.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Myeloid and plasmacytoid dendritic cells (MDC, PDC) play a key role in the initiation of immune responses. We found a reduction of both DC subsets in 42 patients with chronic lymphocytic leukaemia (CLL) at diagnosis (P<0.0001 and 0.0001 vs. controls, respectively), likely related to the high secretion of CCL22 and CXCL 12 (P = 0.04 and 0.008 vs. controls, respectively) by leukaemic cells. However, CD14+ monocytes from CLL patients could give rise to functional IL-12p70-secreting monocyte-derived DCs, capable of inducing a type 1 polorization immunosti-mulatory profile. These monocyte-derived DCs from CLL patients efficiently migrate in response to CCL 19/MIP-3 beta chemokine, suggesting that functional autologous DCs can be generated for immunotherapeutic purposes to circumvent DC defects in CLL. (C) 2007 Elsevier Gmbh. All rights reserved.

引用

页码：493 / 498

页数：6

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