Radial modulation imaging of microbubble contrast agents at high frequency

被引：25

作者：

Cherin, Emmanuel ^{[1
]}

Brown, Jeremy ^{[1
]}

Masoy, Svein-Erik ^{[2
]}

Shariff, Hamid ^{[3
]}

Karshafian, Raffi ^{[3
]}

Williams, Ross ^{[1
]}

Burns, Peter N. ^{[1
,3
]}

Foster, F. Stuart ^{[1
,3
]}

机构：

[1] Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada

[2] Norwegian Univ Sci & Technol, N-7034 Trondheim, Norway

[3] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada

来源：

ULTRASOUND IN MEDICINE AND BIOLOGY | 2008年 / 34卷 / 06期

基金：

加拿大健康研究院;

关键词：

high-frequency ultrasound; microbubbles; contrast agent; radial modulation imaging;

D O I：

10.1016/j.ultrasmedbio.2007.11.017

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

In this paper, radial modulation imaging of microbubbles is investigated at high frequency. A modulation pulse frequency of 3.7 MHz with an amplitude ranging from 0 to 250 kPa, and a 1.3-MPa 20-MHz broadband imaging pulse were used. Radial modulation effects were observed on a population of flowing microbubbles and quantified using a Doppler-type processing technique. Artifact signals related to the generation of harmonics by bubbles strongly resonating at the modulation frequency were observed. The bubble response to simultaneous modulation and imaging excitations was simulated for different combinations of bubble sizes and modulation amplitudes. Simulation results confirm the hypothesis that the generation of harmonics of the modulation frequency can be detected by the imaging transducer. Simulations indicate that the modulation frequency should be chosen lower than the resonant frequency of the biggest bubbles present in the population. The simulation also suggests that a 10% variation of bubble diameter induced by the modulation excitation is sufficient for radial modulation imaging. In conclusion, the effects of radial modulation are detectable at a high frequency. Therefore, radial modulation imaging has potential for high-resolution imaging of microbubbles in the microvasculature. (E-mail: emmanuel.cherin@sri.utoronto.ca) (c) 2008 World Federation for Ultrasound in Medicine & Biology.

引用

页码：949 / 962

页数：14

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