Pd-Catalyzed Oxidative ortho-C-H Borylation of Arenes

被引:163
作者
Dai, Hui-Xiong [1 ]
Yu, Jin-Quan [1 ]
机构
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
关键词
DIRECTED ORTHO BORYLATION; CROSS-COUPLING REACTIONS; ARYL HALIDES; ROOM-TEMPERATURE; FUNCTIONALIZED ARENES; AROMATIC BORYLATION; DIBORON REAGENTS; BOND FORMATION; PALLADIUM; PINACOLBORANE;
D O I
10.1021/ja2097095
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The development of a Pd-catalyzed oxidative ortho-C-H borylation with N-arylbenzamides is reported. A modified dibenzylideneacetone (dba) ligand, a weak base, and a strong oxidant are critical for obtaining good yields. The reaction is tolerant of electron-deficient and electron-rich benzamides derived from readily available benzoic acids. The borylated products can be converted to various synthons via diverse transformations.
引用
收藏
页码:134 / 137
页数:4
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