Chaperone-mediated autophagy: Dice's 'wild' idea about lysosomal selectivity

被引：53

作者：

Cuervo, Ana Maria ^{[1
,2
]}

机构：

[1] Albert Einstein Coll Med, Dept Dev & Mol Biol, Marion Bessin Liver Res Ctr, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Inst Aging Studies, Bronx, NY 10461 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2011年 / 12卷 / 08期

关键词：

RAT-LIVER; ALPHA-SYNUCLEIN; PEPTIDE SEQUENCES; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; RIBONUCLEASE-A; DEGRADATION; PROTEINS; PROTEOLYSIS; RECEPTOR; ACTIVATION;

D O I：

10.1038/nrm3150

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A little over 1 year ago, we lost a bright scientist and a dear colleague who, in his younger years, proposed the 'heretical' idea that lysosomes could selectively degrade cytosolic proteins. That scientist was J. Fred Dice, and his lifetime's discovery was the degradative pathway that we now know as chaperone-mediated autophagy.

引用

页码：535 / 541

页数：7

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