Self-Assembling Peptides as Building Blocks of Functional Materials for Biomedical Applications

被引:93
作者
Fukunaga, Kazuto [1 ]
Tsutsumi, Hiroshi [1 ]
Mihara, Hisakazu [1 ]
机构
[1] Tokyo Inst Technol, Sch Life Sci & Technol, Midori Ku, Nagatsuta Cho 4259 B-40, Yokohama, Kanagawa 2268501, Japan
关键词
Self-assembling peptide; Biomedical application; Cell culture and drug releasing device; DRUG-DELIVERY SYSTEMS; CONTROLLED-RELEASE; STEM-CELLS; EXTRACELLULAR-MATRIX; SUSTAINED-RELEASE; GROWTH-FACTOR; IN-SITU; HYDROGELS; NANOPARTICLES; NANOFIBERS;
D O I
10.1246/bcsj.20180293
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Self-assembling peptides have been explored as building blocks to construct functional materials that can be used in a broad range of biomedical applications. This account gives an overview of the materials built from biomolecules and summarizes the cell culture and drug delivery applications of nanofibrous and hydrogel materials formed via self-assembly of peptides. The design flexibility of materials composed of calcium ion-responsive peptides, which offer a wide range of applications from cell culture scaffolds to drug releasing devices, is highlighted.
引用
收藏
页码:391 / 399
页数:9
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