Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis

被引:11
作者
Zhang, Yan [1 ,2 ]
Chen, Tianyu [1 ,3 ]
Luo, Ping [1 ,4 ]
Li, Shengfa [1 ]
Zhu, Jianwei [5 ]
Xue, Song [6 ]
Cao, Peihua [1 ]
Zhu, Zhaohua [1 ]
Li, Jia [7 ]
Wang, Xiaoshuai [1 ]
Wluka, Anita E. [8 ]
Cicuttini, Flavia [8 ]
Ruan, Guangfeng [1 ,2 ,9 ]
Ding, Changhai [1 ,2 ,8 ,9 ]
机构
[1] Southern Med Univ, Zhujiang Hosp, Clin Res Centre, Guangzhou 510000, Peoples R China
[2] Univ Tasmania, Menzies Inst Med Res, Hobart, Tas 7000, Australia
[3] Southern Med Univ, Dept Orthped, Affiliated Hosp 3, Guangzhou 510000, Peoples R China
[4] Hunan Normal Univ, Changsha Hosp, Dept Spinal Surg, Changsha 410000, Peoples R China
[5] South China Univ Technol, Sch Med, Guangzhou Peoples Hosp 1, Dept Orthoped, Guangzhou 510000, Peoples R China
[6] Anhui Med Univ, Arthrit Res Inst, Dept Rheumatol & Immunol, Affiliated Hosp 1, Hefei 230000, Peoples R China
[7] Southern Med Univ, Nanfang Hosp, Dept Orthpaed, Div Orthpaed Surg, Guangzhou 510000, Peoples R China
[8] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic 3006, Australia
[9] South China Univ Technol, Sch Med, Clin Res Ctr, Guangzhou Peoples Hosp 1, Guangzhou 510000, Peoples R China
基金
英国医学研究理事会; 中国国家自然科学基金;
关键词
osteoarthritis; dietary macroelements; magnesium; potassium; joint structures; symptoms; quality of life; comorbid condition; VITAMIN-D; OLDER-ADULTS; EFFUSION-SYNOVITIS; MAGNESIUM; CARTILAGE; CALCIUM; VOLUME;
D O I
10.3390/nu14173576
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Osteoarthritis (OA), the most common joint disease in the elderly, has no cure. Macroelements are vital in human health and their relationships with OA are not clear. Clarifying the relationships between macroelements and OA may assist knee OA management. Methods: This study was a post-hoc analysis using data from a two-year randomized controlled trial among 392 participants with knee OA. Dietary macroelements, including calcium, magnesium, potassium, and phosphorus were computed-based on a semi-quantitative food frequency questionnaire at baseline. Knee joint structures (including cartilage volume, cartilage defect, bone marrow lesions, and effusion-synovitis volume), OA symptoms, quality of life, and OA comorbid conditions (including lower limb muscle strength and depressive symptoms) were assessed at baseline and month 24. Western Ontario and McMaster Universities (WOMAC) Index and depressive symptoms were assessed at baseline and months 3, 6, 12, and 24. Quality of life and lower limb muscle strength were assessed at baseline and months 6, 12, and 24. All analyses were conducted using mixed-effects models. Results: Higher dietary magnesium and potassium were associated with fewer OA symptoms, higher quality of life, greater lower limb muscle strength, and fewer depressive symptoms, but not with knee joint structures. Higher dietary calcium and phosphorus was not associated with any of the OA-related outcomes, except that dietary phosphorus was associated with greater lower limb muscle strength. Conclusions: In the longitudinal analyses, higher dietary magnesium and potassium intake are associated with fewer OA symptoms, higher quality of life, and milder comorbid conditions in patients with knee OA, suggesting dietary magnesium and potassium may have beneficial effects on OA and could be used for knee OA management.
引用
收藏
页数:11
相关论文
共 41 条
[1]   DEVELOPMENT OF CRITERIA FOR THE CLASSIFICATION AND REPORTING OF OSTEOARTHRITIS - CLASSIFICATION OF OSTEOARTHRITIS OF THE KNEE [J].
ALTMAN, R ;
ASCH, E ;
BLOCH, D ;
BOLE, G ;
BORENSTEIN, D ;
BRANDT, K ;
CHRISTY, W ;
COOKE, TD ;
GREENWALD, R ;
HOCHBERG, M ;
HOWELL, D ;
KAPLAN, D ;
KOOPMAN, W ;
LONGLEY, S ;
MANKIN, H ;
MCSHANE, DJ ;
MEDSGER, T ;
MEENAN, R ;
MIKKELSEN, W ;
MOSKOWITZ, R ;
MURPHY, W ;
ROTHSCHILD, B ;
SEGAL, M ;
SOKOLOFF, L ;
WOLFE, F .
ARTHRITIS AND RHEUMATISM, 1986, 29 (08) :1039-1049
[2]  
Angst F, 2001, ARTHRIT RHEUM-ARTHR, V45, P384, DOI 10.1002/1529-0131(200108)45:4<384::AID-ART352>3.0.CO
[3]  
2-0
[4]  
Baysal O, 2004, SWISS MED WKLY, V134, P283
[5]   Vitamin D supplementation in the management of knee osteoarthritis: study protocol for a randomized controlled trial [J].
Cao, Yuelong ;
Jones, Graeme ;
Cicuttini, Flavia M. ;
Winzenberg, Tania ;
Wluka, Anita ;
Sharman, James ;
Nguo, Kay ;
Ding, Changhai .
TRIALS, 2012, 13
[6]   OSTEOARTHRITIS Is OA a mechanical or systemic disease? [J].
Cicuttini, Flavia M. ;
Wluka, Anita .
NATURE REVIEWS RHEUMATOLOGY, 2014, 10 (09) :515-+
[7]   FACTORS ASSOCIATED WITH UPPER LEG MUSCLE STRENGTH IN KNEE OSTEOARTHRITIS: A SCOPING REVIEW [J].
de Zwart, Arjan H. ;
Dekker, Joost ;
Lems, Willem ;
Roorda, Leo D. ;
van der Esch, Martin ;
van der Leeden, Marike .
JOURNAL OF REHABILITATION MEDICINE, 2018, 50 (02) :140-150
[8]   Risk of Comorbidities Following Physician-Diagnosed Knee or Hip Osteoarthritis: A Register-Based Cohort Study [J].
Dell'Isola, Andrea ;
Pihl, Kenneth ;
Turkiewicz, Aleksandra ;
Hughes, Velocity ;
Zhang, Weiya ;
Bierma-Zeinstra, Sita ;
Prieto-Alhambra, Daniel ;
Englund, Martin .
ARTHRITIS CARE & RESEARCH, 2022, 74 (10) :1689-1695
[9]   Serum Levels of Vitamin D, Sunlight Exposure, and Knee Cartilage Loss in Older Adults The Tasmanian Older Adult Cohort Study [J].
Ding, Changhai ;
Cicuttini, Flavia M. ;
Parameswaran, Venkat ;
Burgess, John ;
Quinn, Steve ;
Jones, Graeme .
ARTHRITIS AND RHEUMATISM, 2009, 60 (05) :1381-1389
[10]  
Erndt-Marino J, 2018, TISSUE ENG PT A, V24, P1390, DOI [10.1089/ten.TEA.2017.0390, 10.1089/ten.tea.2017.0390]