Synthesis and evaluation of the antiproliferative activity of novel isoindolo[2,1-a]quinoxaline and indolo[1,2-a]quinoxaline derivatives

被引：40

作者：

Desplat, Vanessa ^{[1
]}

Moreau, Stephane ^{[1
]}

Belisle-Fabre, Solene ^{[1
]}

Thiolat, Denis ^{[2
]}

Uranga, Juliette ^{[1
]}

Lucas, Romain ^{[1
]}

de Moor, Laure ^{[1
]}

Massip, Stephane ^{[1
]}

Jarry, Christian ^{[1
]}

Mossalayi, Djavad M. ^{[2
]}

Sonnet, Pascal ^{[3
]}

Deleris, Gerard ^{[1
]}

Guillon, Jean ^{[1
]}

机构：

[1] Univ Bordeaux Segalen, CNRS, FRE 3396, Bordeaux, France

[2] Univ Bordeaux Segalen, PPF Medicaments Parasitol, Bordeaux, France

[3] Univ Picardie Jules Verne, Lab Glucides, Fac Pharm, CNRS,UMR 6219, Amiens, France

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2011年 / 26卷 / 05期

关键词：

Isoindolo[2,1-a]quinoxaline; indolo[1,2-a]quinoxaline; antiproliferative agents; CROSS-COUPLING REACTIONS; ANTILEISHMANIAL AGENTS; ANTIMALARIAL ACTIVITY; POTENTIAL INHIBITORS; IN-VITRO; HETEROCYCLES; APOPTOSIS; PATHWAY; CELLS;

D O I：

10.3109/14756366.2010.548326

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel series of isoindolo[2,1-a]quinoxaline and indolo[1,2-a]quinoxaline derivatives was synthesized and evaluated in vitro against various human cancer cell lines for antiproliferative activity. These new compounds displayed activity against leukemia and breast cancer cell lines in the 3- to 18-mu M concentration range.

引用

页码：657 / 667

页数：11

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