Antifungal activity of aqueous and methanolic extracts from the Mediterranean sea cucumber, Holothuria polii

被引：36
作者：
Ismail, H. [1 ,2 ]
Lemriss, S. [3 ,4 ,5 ,6 ]
Ben Aoun, Z. [1 ,2 ]
Mhadhebi, L. [1 ,2 ]
Dellai, A. [1 ,2 ]
Kacem, Y. [1 ,2 ]
Boiron, P. [3 ,4 ,5 ,6 ]
Bouraoui, A. [1 ,2 ]
机构：
[1] Fac Pharm, Unite Rech Ursam, Monastir 5000, Tunisia
[2] Fac Sci, Unite Rech Chim Organ Asymet, Monastir 5000, Tunisia
[3] Univ Lyon 1, Grp Rech Pathogenes Opportunistes & Environm, F-69003 Lyon, France
[4] Univ Lyon 1, UMR 5557, F-69622 Villeurbanne, France
[5] Ecole Natl Vet, F-69280 Marcy Letoile, France
[6] Inst Sci Pharmaceut & Biol, F-69373 Lyon, France
来源：
JOURNAL DE MYCOLOGIE MEDICALE | 2008年 / 18卷 / 01期
关键词：
Holothuria polii; antifungal activity; aqueous extract; methanolic extract; purification; semi-purified fractions;
D O I：
10.1016/j.mycmed.2008.01.002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Crude extracts and semi-purified fractions (F5, F6) from the Mediterranean sea cucumber, Holothuria polii, collected from the bay of Tabarka (Tunisia coast) were evaluated for their antifungal activity against filamentous fungi and yeast. The activity was determined in vitro, using the well. diffusion test in the casitone agar medium. Both the aqueous and the methanolic extracts were found to produce, in a concentration-related manner (600-1500 mu g/well) a significant antifungal activity. The semi-purified fractions (F5, F6) of both extracts exhibited also a significant antifungal activity in a concentration-related manner (150-300 mu g/well). The strains of Aspergillus fumigatus were more susceptible to these extracts and derived fractions, while those of Trichophyton rubrurn were found to be less susceptible. No activity was observed against strains of Candida albicans. These findings suggest that the polar active fractions (F5, F6)obtained from aqueous and methanolic extracts could contain anew antifungal compound(s). The purification and the determination of chemical structure of compound(s) of these active fractions are under investigation. (C) 2008 Elsevier Masson SAS. All rights reserved.
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页码：23 / 26
页数：4
相关论文
共 20 条
  • [1] New diterpene glycosides of the fungus Acremonium striatisporum isolated from a sea cucumber
    Afiyatullov, Shamil Sh.
    Kalinovsky, Anatoly I.
    Pivkin, Mikhail V.
    Dmitrenok, Pavel S.
    Kuznetsova, Tatyana A.
    [J]. NATURAL PRODUCT RESEARCH, 2006, 20 (10) : 902 - 908
  • [2] Aminin D. L., 2001, J Med Food, V4, P127, DOI 10.1089/109662001753165701
  • [3] ANISIMOV MM, 1972, DOKL AKAD NAUK SSSR+, V207, P711
  • [4] SCREENING OF MARINE-INVERTEBRATES FOR THE PRESENCE OF ERGOSTEROL-SENSITIVE ANTIFUNGAL COMPOUNDS
    ANTONIO, J
    MOLINSKI, TF
    [J]. JOURNAL OF NATURAL PRODUCTS, 1993, 56 (01): : 54 - 61
  • [5] Antibacterial and antifungal agents from Egyptian marine organisms
    Badria, FA
    Guirguis, AN
    El-Naggar, WA
    [J]. INTERNATIONAL JOURNAL OF PHARMACOGNOSY, 1997, 35 (04): : 284 - 287
  • [6] DEFENSIVE MECHANISMS AND ECOLOGY OF SOME TROPICAL HOLOTHURIANS
    BAKUS, GJ
    [J]. MARINE BIOLOGY, 1968, 2 (01) : 23 - &
  • [7] BATRAKOV SG, 1980, ANTIBIOT MED BIOTEK, V25, P408
  • [8] STUDIES ON HOLOTHURIA-POLII (ECHINODERMATA) ANTIBACTERIAL PROTEINS .1. EVIDENCE FOR AND ACTIVITY OF A COELOMOCYTE LYSOZYME
    CANICATTI, C
    ROCH, P
    [J]. EXPERIENTIA, 1989, 45 (08): : 756 - 759
  • [9] CANICATTI C, 1991, COMP BIOCHEM PHYS B, V98, P93
  • [10] Cytotoxic and antifungal triterpene glycosides from the Patagonian sea cucumber Hemoiedema spectabilis
    Chludil, HD
    Muniain, CC
    Seldes, AM
    Maier, MS
    [J]. JOURNAL OF NATURAL PRODUCTS, 2002, 65 (06): : 860 - 865
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